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首页> 外文期刊>Mediators of inflammation >Association between Brain-Derived Neurotrophic Factor (BDNF) Levels in 2(nd) Trimester Amniotic Fluid and Fetal Development
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Association between Brain-Derived Neurotrophic Factor (BDNF) Levels in 2(nd) Trimester Amniotic Fluid and Fetal Development

机译:脑源性神经营养因子(BDNF)水平在2(ND)三三月植物液和胎儿发育中的关联

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摘要

The development of the fetal nervous system mirrors general fetal development, comprising a combination of genetic resources and effects of the intrauterine environment. Our aim was to assess the 2(nd) trimester amniotic fluid levels of brain-derived neurotrophic factor (BDNF) and to investigate its association with fetal growth. In accordance with our study design, samples of amniotic fluid were collected from women who had undergone amniocentesis early in the 2(nd) trimester. All pregnancies were followed up until delivery and fetal growth patterns and birth weights were recorded, following which pregnancies were divided into three groups based on fetal weight: (1) AGA (appropriate for gestational age), (2) SGA (small for gestational age), and (3) LGA (large for gestational age). We focused on these three groups representing a reflection of the intrauterine growth spectrum. Our results revealed the presence of notably higher BDNF levels in the amniotic fluid of impaired growth fetuses by comparison with those of normal growth. Both SGA and macrosomic fetuses are characterized by notably higher amniotic fluid levels of BDNF (mean values of 36,300pg/ml and 35,700pg/ml, respectively) compared to normal-growth fetuses (mean value of 32,700pg/ml). Though apparently small, this difference is, nevertheless, statistically significant (p value<0.05) in SGA fetuses in the extremes of the distribution, i.e., below the 3rd centile. In conclusion, there is clear evidence that severe impairment of fetal growth induces the increased production of fetal brain growth factor as an adaptive mechanism in reaction to a hostile intrauterine environment, thereby accelerating fetal brain development and maturation.
机译:胎儿神经系统的发展反映了一般胎儿发育,包括遗传资源的组合和宫内环境的影响。我们的目的是评估脑衍生的神经营养因子(BDNF)的2(ND)三孕季霉菌水平,并研究其与胎儿生长的关系。按照我们的研究设计,从2(ND)三三月早期经过羊膜穿刺术的女性收集羊水样品。随访所有怀孕,直到记录递送和胎儿生长模式和出生体重,然后根据胎儿重量分为三组妊娠:(1)AGA(适合孕期),(2)SGA(胎龄小) ),(3)LGA(胎龄大)。我们专注于这三组,代表宫内生长谱的反映。我们的研究结果表明,通过与正常生长的比较,通过与正常生长的比较,揭示羊水中的羊水中羊水中的较高BDNF水平。 SGA和宏观组织胎儿的特征在于与正常生长胎儿(平均值为32,700pg / ml)的BDNF(分别为36,300pg / ml和35,700pg / ml的平均值为36,300pg / ml和35,700pg / ml的平均值)。尽管显然小,但是,这种差异是在分布的极端分布的极端情况下的统计学意义(P值<0.05),即,在第3厘米之下。总之,有明确的证据表明胎儿生长的严重损害诱导胎儿脑生长因子的产量增加,作为对敌对宫内环境反应的自适应机制,从而加速胎儿脑发育和成熟。

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  • 来源
    《Mediators of inflammation》 |2018年第ptav期|共7页
  • 作者单位

    Natl &

    Kapodistrian Univ Athens Med Sch Aretaieio Hosp Dept Obstet &

    Gynecol 2 Athens Greece;

    Natl &

    Kapodistrian Univ Athens Med Sch Aretaieio Hosp Dept Obstet &

    Gynecol 2 Athens Greece;

    Natl &

    Kapodistrian Univ Athens Med Sch Aretaieio Hosp Dept Obstet &

    Gynecol 2 Athens Greece;

    Metaxa Canc Hosp Gynecol Oncol Dept Piraeus Greece;

    Univ Thessaly Larissa Univ Hosp Med Sch Dept Endocrinol &

    Metab Disorders Larisa Greece;

    Natl &

    Kapodistrian Univ Athens Med Sch Aretaieio Hosp Dept Obstet &

    Gynecol 2 Athens Greece;

    St Georges Univ London Med Sch London England;

    Aghia Sophia Childrens Hosp Dept Clin Biochem Athens Greece;

    Natl &

    Kapodistrian Univ Athens Med Sch Aretaieio Hosp Dept Obstet &

    Gynecol 2 Athens Greece;

    Natl &

    Kapodistrian Univ Athens Med Sch Aretaieio Hosp Dept Obstet &

    Gynecol 2 Athens Greece;

    Natl &

    Kapodistrian Univ Athens Med Sch Aretaieio Hosp Dept Obstet &

    Gynecol 2 Athens Greece;

    Natl &

    Kapodistrian Univ Athens Med Sch Aretaieio Hosp Dept Obstet &

    Gynecol 2 Athens Greece;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 病理学;
  • 关键词

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