To diagnose or not to diagnose? Timing is the question: balancing early diagnosis of multiple sclerosis with misdiagnosis

摘要

Multiple sclerosis (MS) is a neurodegenerative central nervous system (CNS) demyelinating disease with clinical and radiologic heterogeneity in which a pathognomonic biomarker has yet to be uncovered. Consequently, atypical presentations of MS can present a diagnostic challenge, especially in those patients who do not initially fit the classic picture of clinically isolated syndrome (CIS) and/or those who do not fulfill the 2010 McDonald criteria for MS [1,2].