Validation of highly accelerated real‐time cardiac cine MRI with radial k‐space sampling and compressed sensing in patients at 1.5T and 3T

摘要

Purpose To validate an optimal 12‐fold accelerated real‐time cine MRI pulse sequence with radial k‐space sampling and compressed sensing (CS) in patients at 1.5T and 3T. Methods We used two strategies to reduce image artifacts arising from gradient delays and eddy currents in radial k‐space sampling with balanced steady‐state free precession readout. We validated this pulse sequence against a standard breath‐hold cine sequence in two patient cohorts: a myocardial infarction ( n ?=?16) group at 1.5T and chronic kidney disease group ( n ?=?18) at 3T. Two readers independently performed visual analysis of 68 cine sets in four categories (myocardial definition, temporal fidelity, artifact, noise) on a 5‐point Likert scale (1?=?nondiagnostic, 2?=?poor, 3?=?adequate or moderate, 4?=?good, 5?=?excellent). Another reader calculated left ventricular (LV) functional parameters, including ejection fraction. Results Compared with standard cine, real‐time cine produced nonsignificantly different visually assessed scores, except for the following categories: 1) temporal fidelity scores were significantly lower ( P ?=?0.013) for real‐time cine at both field strengths, 2) artifacts scores were significantly higher ( P ?=?0.013) for real‐time cine at both field strengths, and 3) noise scores were significantly ( P ?=?0.013) higher for real‐time cine at 1.5T. Standard and real‐time cine pulse sequences produced LV functional parameters that were in good agreement (e.g., absolute mean difference in ejection fraction 4%). Conclusion This study demonstrates that an optimal 12‐fold, accelerated, real‐time cine MRI pulse sequence using radial k‐space sampling and CS produces good to excellent visual scores and relatively accurate LV functional parameters in patients at 1.5T and 3T. Magn Reson Med 79:2745–2751, 2018. ? 2017 International Society for Magnetic Resonance in Medicine.