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首页> 外文期刊>Magnetic Resonance in Chemistry: MRC >perfectperfect BASHBASH : Band‐selective homonuclear decoupling in peptides and peptidomimetics
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perfectperfect BASHBASH : Band‐selective homonuclear decoupling in peptides and peptidomimetics

机译： perfect perfect bash Bash：肽和肽肽中的带选择性同核去耦

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Abstract > Pure shift techniques have recently attracted much attention, as they have the ability to reduce spectral overlap and thus to simplify the analysis of complex and congested spectral regions. For peptides, band‐selective pure shift approaches are often the most reasonable choice among these, when spectra need to be simplified along proton dimensions. Band‐selective approaches usually offer the highest sensitivity of all pure shift methods, albeit at the cost that signals can only be acquired in a single‐frequency region of the spectrum, in which protons are well isolated in the proton spectrum. For α‐peptides, signals are usually acquired either in the amide‐proton region or in the α‐proton region. Herein, we present experiments, which enable the pure shift acquisition in both the amide‐proton and the α‐proton regions of α‐peptides simultaneously, without sacrificing the characteristics of band‐selective pure shift methods to provide high sensitivity. The “ perfect BASH” approach discussed here combines the perfect echo experiment with band‐selective decoupling. It can be used for band‐selective pure shift acquisition of 1 H, TOCSY, CLIP‐COSY, relayed CLIP‐COSY, NOESY, and EASY‐ROESY spectra, with proton–proton decoupling over the full backbone region of α‐peptides, which is most interesting for samples prepared without isotopic enrichment. As the utility of this technique is by no means limited to α‐peptides, we further illustrate its utility for 1 H‐NMR studies of a peptidomimetic oligourea. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“de”> <title type =“main”>抽象</ title> >纯移位技术最近引起了很多关注，因为它们具有降低光谱重叠的能力，从而简化了复杂和拥塞光谱区域的分析。对于肽，当需要沿质子尺寸简化光谱时，带选择性纯移位通常是最合理的选择。带选择方法通常提供所有纯移位方法的最高灵敏度，尽管在频谱的单频区域中只能获得信号的成本，其中质子在质子谱中很好地分离。对于α-肽，通常在酰胺 - 质子区域或α-质子区域中获取信号。在此，我们存在实验，该实验使得在酰胺质子和α-肽的α-质子区域同时能够同时进行纯移植物，而不牺牲带选择纯移位方法的特性以提供高灵敏度。这里讨论的“完美</ i> bash”方法结合了带有乐队选择性解耦的完美回声实验。它可用于带有选择性纯移植的 1 </ sup> h，tocsy，剪辑舒适，继承的夹子舒适，noesy和易罗塞斯谱，用proton-proton在完整的骨干上解耦对于没有同位素富集的样品，α-肽的区域最有趣。由于该技术的效用绝不限于α-肽，因此我们进一步说明了肽咪芦藻的 1 </ sup> H-NMR研究的效用。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-24320/'>《Magnetic Resonance in Chemistry: MRC》</a> <b style="margin: 0 2px;">|</b><span>2018年第10speca期</span><b style="margin: 0 2px;">|</b><span>共16页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ilgen Julian&option=202" target="_blank" rel="nofollow">Ilgen Julian;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kaltschnee Lukas&option=202" target="_blank" rel="nofollow">Kaltschnee Lukas;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Thiele Christina M.&option=202" target="_blank" rel="nofollow">Thiele Christina M.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Clemens‐Sch?pf‐Institut für Organische Chemie und BiochemieTechnische Universit?t DarmstadtDarmstadt Germany;</p> <p>Clemens‐Sch?pf‐Institut für Organische Chemie und BiochemieTechnische Universit?t DarmstadtDarmstadt Germany;</p> <p>Clemens‐Sch?pf‐Institut für Organische Chemie und BiochemieTechnische Universit?t DarmstadtDarmstadt Germany;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/13344.html" title="磁化学分析法">磁化学分析法;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=1 H‐NMR&option=203" rel="nofollow">1 H‐NMR;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=2D NMR&option=203" rel="nofollow">2D NMR;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=band‐selective homonuclear (BASH) decoupling&option=203" rel="nofollow">band‐selective homonuclear (BASH) decoupling;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=full sensitivity&option=203" rel="nofollow">full sensitivity;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=NMR&option=203" rel="nofollow">NMR;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=peptides&option=203" rel="nofollow">peptides;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=peptidomimetics&option=203" rel="nofollow">peptidomimetics;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=perfect echo&option=203" rel="nofollow">perfect echo;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=pure shift&option=203" rel="nofollow">pure shift;</a> </p> <div class="translation"> 机译：1 H-NMR;2D NMR;带选择性同核（BASH）去耦;完全敏感性;NMR;肽;肽模拟物;完美的回声;纯换档; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023546106.html"><fi xmlns="http://www.wiley.com/namespaces/wiley">perfect</fi>perfect <fc xmlns="http://www.wiley.com/namespaces/wiley">BASH</fc>BASH : Band‐selective homonuclear decoupling in peptides and peptidomimetics</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ilgen Julian&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Ilgen Julian,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kaltschnee Lukas&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kaltschnee Lukas,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Thiele Christina M.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Thiele Christina M. </a> <a href="/journal-foreign-24320/" target="_blank" rel="nofollow" class="tuijian_authcolor">Magnetic Resonance in Chemistry: MRC .</a> <span>2018</span><span>,第10Speca期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：<fi xmlns =“http://www.wiley.com/namespaces/wiley”> perfect </ fi> perfect <fc xmlns =“http://www.wiley.com/namespaces/wiley”> bash </ fc > Bash：肽和肽肽中的带选择性同核去耦</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025121631.html"><fi xmlns="http://www.wiley.com/namespaces/wiley"> <fc>HLA</fc> ‐B*40:01:45 </fi> <fc xmlns="http://www.wiley.com/namespaces/wiley">HLA</fc>HLA ‐B*40:01:45 , a novel variant of <fi xmlns="http://www.wiley.com/namespaces/wiley"> <fc>HLA</fc> ‐B*40:01 </fi> <fc xmlns="http://www.wiley.com/namespaces/wiley">HLA</fc>HLA ‐B*40:01 , discovered in a Taiwanese hematopoitic stem cell donor</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang K. 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Y. </a> <a href="/journal-foreign-32551/" target="_blank" rel="nofollow" class="tuijian_authcolor">HLA. .</a> <span>2017</span><span>,第5期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：发现一个小说的<fi xmlns =“http://www.wiley.com/namespaces/wiley”> <fc> hla </ fc> -a * 02 </ fi> <fc xmlns =“http：// www .wiley.com /命名空间/ wiley“> hla </ fc> hla -a * 02变体，<fi xmlns =”http://www.wiley.com/namespaces/wiley“> <fc> hla </ fc> -a * 02：684，</ fi> <fc xmlns =“http://www.wiley.com/namespaces/wiley”> hla </ fc> hla -a * 02：684，在台湾个人</span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" 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