Graphene‐Oxide‐Decorated Microporous Polyetheretherketone with Superior Antibacterial Capability and In Vitro Osteogenesis for Orthopedic Implant

Ouyang Ling; Deng Yi; Yang Lei; Shi Xiuyuan; Dong Taosheng; Tai Youyi; Yang Weizhong; Chen Zhi‐Gang

摘要

Abstract > Due to its similar elastic modulus of human bones, polyetheretherketone (PEEK) has been considered as an excellent cytocompatible material. However, the bioinertness, poor osteoconduction, and weak antibacterial activity of PEEK limit its wide applications in clinics. In this study, a facile strategy is developed to prepare graphene oxide (GO) modified sulfonated polyetheretherketone (SPEEK) (GO‐SPEEK) through a simple dip‐coating method. After detailed characterization, it is found that the GO closely deposits on the surface of PEEK, which is attributed to the π–π stacking interaction between PEEK and GO. Antibacterial tests reveal that the GO‐SPEEK exhibits excellent suppression toward Escherichia coli . In vitro cell attachment, growth, differentiation, alkaline phosphatase activity, quantitative real‐time polymerase chain reaction analyses, and calcium mineral deposition all illustrate that the GO‐SPEEK substrate can significantly accelerate the proliferation and osteogenic differentiation of osteoblast‐like MG‐63 cells compared with those on PEEK and SPEEK groups. These results suggest that the GO‐SPEEK has an improved antibacterial activity and cytocompatibility in vitro, showing that the developed GO‐SPEEK has a great potential as the bioactive implant material in bone tissue engineering. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：Lang =“en”> <标题类型=“main”>摘要</标题> >由于其类似的人体骨骼弹性模量，聚醚醚酮（PEEK）被认为是一种优异的细胞势能材料。然而，PEEK的生物营养性，疏松疏松术和弱抗菌活性限制了其在诊所的广泛应用。在该研究中，开发了一种容易策略以通过简单的浸涂方法制备石墨烯氧化物（GO）改性磺化聚醚醚酮（Speek）（Go-Speek）。在详细表征之后，发现距离Peek表面的沉积物紧密沉积，这归因于Peek之间的π-π堆叠相互作用。抗菌试验表明，Go-Speek表现出对大肠杆菌的优异抑制。体外细胞附着，生长，分化，碱性磷酸酶活性，定量实时聚合酶链反应分析和钙矿物沉积均说明了Go-Speek底物可以显着加速成骨细胞样MG-63细胞的增殖和成骨分化与Peek和Speek群体相比。这些结果表明，Go-Speek在体外具有改善的抗菌活性和细胞粘合性，表明发育的Go-Speek具有骨组织工程中的生物活性植入物质的巨大潜力。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-24307/'>《Macromolecular bioscience》</a> <b style="margin: 0 2px;">|</b><span>2018年第6期</span><b style="margin: 0 2px;">|</b><span>共13页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ouyang Ling&option=202" target="_blank" rel="nofollow">Ouyang Ling;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Deng Yi&option=202" target="_blank" rel="nofollow">Deng Yi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Lei&option=202" target="_blank" rel="nofollow">Yang Lei;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shi Xiuyuan&option=202" target="_blank" rel="nofollow">Shi Xiuyuan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dong Taosheng&option=202" target="_blank" rel="nofollow">Dong Taosheng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tai Youyi&option=202" target="_blank" rel="nofollow">Tai Youyi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Weizhong&option=202" target="_blank" rel="nofollow">Yang Weizhong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Zhi‐Gang&option=202" target="_blank" rel="nofollow">Chen Zhi‐Gang;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>School of Materials Science and EngineeringSichuan UniversityChengdu 610065 China;</p> <p>School of Chemical EngineeringSichuan UniversityChengdu 610065 China;</p> <p>School of Materials Science and EngineeringSichuan UniversityChengdu 610065 China;</p> <p>School of Materials Science and EngineeringSichuan UniversityChengdu 610065 China;</p> <p>School of Materials Science and EngineeringSichuan UniversityChengdu 610065 China;</p> <p>School of Materials Science and EngineeringSichuan UniversityChengdu 610065 China;</p> <p>School of Materials Science and EngineeringSichuan UniversityChengdu 610065 China;</p> <p>Centre for Future MaterialsUniversity of Southern QueenslandSpringfield QLD 4300 Australia;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1185.html" title="高分子化学（高聚物）">高分子化学（高聚物）;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=antibacterial activity&option=203" rel="nofollow">antibacterial activity;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cytocompatibility&option=203" rel="nofollow">cytocompatibility;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=graphene oxide&option=203" rel="nofollow">graphene oxide;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=osteogenic differentiation&option=203" rel="nofollow">osteogenic differentiation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=polyetheretherketone&option=203" rel="nofollow">polyetheretherketone;</a> </p> <div class="translation"> 机译：抗菌活性;细胞锁定性;石墨烯氧化物;成骨分化;聚醚醚酮; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023543222.html">Graphene‐Oxide‐Decorated Microporous Polyetheretherketone with Superior Antibacterial Capability and In Vitro Osteogenesis for Orthopedic Implant</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ouyang Ling&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Ouyang Ling,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Deng 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