Chitosan‐Based Thermo/pH Double Sensitive Hydrogel for Controlled Drug Delivery

Bai Xiaoyu; Bao Zixian; Bi Shichao; Li Yang; Yu Xiaoping; Hu Shihao; Tian Meiping; Zhang Xin; Cheng Xiaojie; Chen Xiguang

摘要

Abstract > A series of thermo/pH sensitive N ‐succinyl hydroxybutyl chitosan (NSHBC) hydrogels with different substitution degrees of succinyl are prepared for drug delivery. Rheology analysis shows that the gelation temperature of NSHBC hydrogels is 3.8 °C higher than that of hydroxybutyl chitosan (HBC) hydrogels. A model drug bovine serum albumin (BSA) is successfully loaded and released. NSHBC hydrogels show excellent pH sensitivity drug release behaviors. After incubation for 24 h, 93.7% of BSA is released from NSHBC hydrogels in phosphate buffer saline (PBS) (pH 7.4), which is significantly greater than that of 24.6% at pH 3.0. In contrast, the release rate of BSA from HBC is about 70.0% at pH 3.0 and 7.4. Thus, these novel hydrogels have the prominent merits of high adaptability to soluble drugs and pH sensitivity triggered release, indicating that NSHBC hydrogels have promising applications in oral drug delivery. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract type =“main”xml：lang =“en”> <title type =“main”>抽象</ title> >一系列热/ pH敏感性 n </ i> - 辛丙氨酸羟基丁基酸壳多糖（NSHBC）制备具有不同取代琥珀酰基琥珀酰基的水凝胶用于给药。流变学分析表明，NSHBC水凝胶的凝胶化温度高于3.8℃高于羟基丁糖丁糖（HBC）水凝胶的3.8℃。成功装载和释放模型药物牛血清白蛋白（BSA）。 NSHBC水凝胶显示出优异的pH敏感性药物释放行为。孵育24小时后，93.7％的BSA从NSHBC水凝胶中释放出磷酸盐缓冲盐水（PB）（pH7.4），其在pH 3.0下显着大于24.6％。相反，HBC的BSA的释放速率在pH 3.0和7.4时约为70.0％。因此，这些新的水凝胶具有高适应性对可溶性药物和pH敏感性触发的突出优点，表明NSHBC水凝胶在口服药物递送中具有有希望的应用。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-24307/'>《Macromolecular bioscience》</a> <b style="margin: 0 2px;">|</b><span>2018年第3期</span><b style="margin: 0 2px;">|</b><span>共12页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bai Xiaoyu&option=202" target="_blank" rel="nofollow">Bai Xiaoyu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bao Zixian&option=202" target="_blank" rel="nofollow">Bao Zixian;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bi Shichao&option=202" target="_blank" rel="nofollow">Bi Shichao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Yang&option=202" target="_blank" rel="nofollow">Li Yang;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yu Xiaoping&option=202" target="_blank" rel="nofollow">Yu Xiaoping;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hu Shihao&option=202" target="_blank" rel="nofollow">Hu Shihao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tian Meiping&option=202" target="_blank" rel="nofollow">Tian Meiping;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Xin&option=202" target="_blank" rel="nofollow">Zhang Xin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cheng Xiaojie&option=202" target="_blank" rel="nofollow">Cheng Xiaojie;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Xiguang&option=202" target="_blank" rel="nofollow">Chen Xiguang;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>College of Marine Life ScienceOcean University of ChinaQingdao 266003 P. R. China;</p> <p>Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesShandong 266101 P. R. China;</p> <p>College of Marine Life ScienceOcean University of ChinaQingdao 266003 P. R. China;</p> <p>College of Marine Life ScienceOcean University of ChinaQingdao 266003 P. R. China;</p> <p>College of Marine Life ScienceOcean University of ChinaQingdao 266003 P. R. China;</p> <p>College of Marine Life ScienceOcean University of ChinaQingdao 266003 P. R. China;</p> <p>College of Marine Life ScienceOcean University of ChinaQingdao 266003 P. R. China;</p> <p>College of Marine Life ScienceOcean University of ChinaQingdao 266003 P. R. China;</p> <p>College of Marine Life ScienceOcean University of ChinaQingdao 266003 P. R. China;</p> <p>College of Marine Life ScienceOcean University of ChinaQingdao 266003 P. R. China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1185.html" title="高分子化学（高聚物）">高分子化学（高聚物）;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=hydrogel&option=203" rel="nofollow">hydrogel;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=hydroxybutyl chitosan&option=203" rel="nofollow">hydroxybutyl chitosan;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=oral delivery&option=203" rel="nofollow">oral delivery;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=thermo/pH double sensitive&option=203" rel="nofollow">thermo/pH double sensitive;</a> </p> <div class="translation"> 机译：水凝胶;羟基丁基壳聚糖;口服递送;热/ pH双敏感; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023543042.html">Chitosan‐Based Thermo/pH Double Sensitive Hydrogel for Controlled Drug Delivery</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bai Xiaoyu&option=202" target="_blank" rel="nofollow" class="tuijian_auth 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href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=周进雄&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,周进雄</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李梅娥&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李梅娥</a> <span> <a href="/conference-cn-11514/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国力学大会2011暨钱学森诞辰100周年纪念大会 </a> <span> <span> . 2011</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020313579229.html">基于双载模式的聚合物胶束用于多西他赛的pH敏感递送</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=苏志会&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 苏志会</a> <span> . 2016</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120109367668.html">一种羧甲基壳聚糖pH敏感性水凝胶药物载体的制备方法</a> <b>[P]</b> . <span> 中国专利： CN106860871A </span> <span> . 2017-06-20</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/061202539732.html">pH敏感性载体及其制造方法、以及含有该载体的pH敏感性药物、pH敏感性药物组合物及使用其的培养方法</a> <b>[P]</b> . <span> 中国专利： CN104334194B </span> <span> . 2017.08.22</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130429547238.html">THERMO-SENSITIVE POLYMER HYDROGELS HAVING INTERPENETRATING POLYMER NETWORK STRUCTURE, PREPARATION METHOD THEREOF AND INJECTABLE DRUG DELIVERY SYSTEM COMPRISING THE SAME</a> <b>[P]</b> . <span> 外国专利：  KR20090002946A </span> <span> . 2009-01-09</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：具有互穿聚合物网络结构的热敏性聚合物水合物，其制备方法和包含其的可注射药物输送系统 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130416705238.html">DRUG DELIVERY SYSTEM BASED ON INTERVENTIONAL INJECTION OF TEMPERATURE AND pH-SENSITIVE INJECTABLE HYDROGEL</a> <b>[P]</b> . <span> 外国专利：  KR101384991B1 </span> <span> . 2014-06-17</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：基于温度和pH敏感性可注射水的干预注射的药物输送系统 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130419501617.html">DRUG DELIVERY SYSTEM BASED ON INTERVENTIONAL INJECTION OF TEMPERATURE AND PH-SENSITIVE INJECTABLE HYDROGEL</a> <b>[P]</b> . <span> 外国专利：  KR20130010402A </span> <span> . 2013-01-28</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：基于温度和PH敏感性可注射水的干预注射的药物输送系统 </span> </p> </li> </ul> </div> </div> </div> <div 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