Impact of total body weight on 30-day mortality in patients with gram-negative bacteremia

摘要

Background: The impact of total body weight (TBW) on 30-day mortality associated with gram-negative bacteremia has not been previously evaluated.Methods: The cohort included 323 patients >/=18years old with gram-negative bacteremia (1/1/2008-8/31/2011) who received >/=48hours of antibiotics. We compared 30-day mortality of TBW /=70 kg with a multivariable stepwise logistic regression adjusting for age >/=70years, cancer diagnosis, and Pitt bacteremia score of >/=4.Results: The cohort was 57% TBW >/=70 kg and 43% TBW /=70 kg patients had lower 30-day mortality (11.0% vs. 16.3%), which was significant in the multivariable analysis (OR 0.45, 95% CI 0.21-0.97). Cancer and Pitt bacteremia score >/=4 were also independently associated with 30-day mortality. TBW was no longer significant when TBW /=70 kg was associated with an improved 30-day mortality; however, the high mortality rates for patients with a TBW < 50 kg is responsible for this association.