gamma-Glutamyl cyclotransferase contributes to tumor progression in high grade serous ovarian cancer by regulating epithelial-mesenchymal transition via activating PI3K/AKT/mTOR pathway

Li Yanli; Wu Tingting; Wang Yanan; Yang Liu; Hu Chengcheng; Chen Limo; Wu Sufang

首页> 外文期刊>Gynecologic Oncology: An International Journal >gamma-Glutamyl cyclotransferase contributes to tumor progression in high grade serous ovarian cancer by regulating epithelial-mesenchymal transition via activating PI3K/AKT/mTOR pathway

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gamma-Glutamyl cyclotransferase contributes to tumor progression in high grade serous ovarian cancer by regulating epithelial-mesenchymal transition via activating PI3K/AKT/mTOR pathway

机译：通过激活PI3K / AKT / MTOR途径调节上皮间充质转化，γ-戊二基循环转移酶通过调节上皮 - 间充质转换来促进高级浆膜癌癌中的肿瘤进展

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Objective. High grade serous ovarian cancer (HGSC) remains one of the most lethal malignancies in females. We previously reported that gamma-glutamyl cyclotransferase (GGCT) was significantly upregulated in serous ovarian cancer. The current study was aimed to explore the function and underlying mechanism of GGCF in HGSC.

机译：客观的。高级浆液性卵巢癌（HGSC）仍然是女性最致命的恶性肿瘤之一。我们之前报道γ-谷氨酸循环转移酶（GGCT）在浆液性卵巢癌中显着上调。目前的研究旨在探讨HGSC中GGCF的功能和潜在机制。

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来源
《Gynecologic Oncology: An International Journal》 |2018年第1期|共10页
作者
Li Yanli; Wu Tingting; Wang Yanan; Yang Liu; Hu Chengcheng; Chen Limo; Wu Sufang;
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作者单位

Shanghai Jiao Tong Univ Sch Med Shanghai Gen Hosp Dept Obstet &

Gynecol 100 Haining Rd;

Shanghai Jiao Tong Univ Sch Med Shanghai Gen Hosp Dept Obstet &

Gynecol 100 Haining Rd;

Shanghai Jiao Tong Univ Sch Med Shanghai Gen Hosp Dept Obstet &

Gynecol 100 Haining Rd;

Shanghai Jiao Tong Univ Sch Med Shanghai Gen Hosp Dept Obstet &

Gynecol 100 Haining Rd;

Shanghai Jiao Tong Univ Sch Med Shanghai Gen Hosp Dept Obstet &

Gynecol 100 Haining Rd;

Univ Texas MD Anderson Canc Ctr Dept Thorac Head &

Neck Med Oncol 1515 Holcombe Blvd Houston TX;

Shanghai Jiao Tong Univ Sch Med Shanghai Gen Hosp Dept Obstet &

Gynecol 100 Haining Rd;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Ovarian cancer; gamma-Glutamyl cyclotransferase; Tumor spread; Epithelial-mesenchymal transition; Prognosis;

机译：卵巢癌;γ-谷氨酸旋转转剂酶;肿瘤扩散;上皮 - 间充质转换;预后;

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专利

1. gamma-Glutamyl cyclotransferase contributes to tumor progression in high grade serous ovarian cancer by regulating epithelial-mesenchymal transition via activating PI3K/AKT/mTOR pathway [J] . Li Yanli, Wu Tingting, Wang Yanan, Gynecologic Oncology: An International Journal . 2018,第1期

机译：通过激活PI3K / AKT / MTOR途径调节上皮间充质转化，γ-戊二基循环转移酶通过调节上皮 - 间充质转换来促进高级浆膜癌癌中的肿瘤进展
2. SNCG promotes the progression and metastasis of high-grade serous ovarian cancer via targeting the PI3K/AKT signaling pathway [J] . Jing Zhang, Xiao-han Liu, Cong Li, Journal of experimental & clinical cancer research : . 2020,第1期

机译：SNCG通过靶向PI3K / AKT信号通路促进高级浆液卵巢癌的进展和转移
3. Lysine demethylase 2A promotes the progression of ovarian cancer by regulating the PI3K pathway and reversing epithelial-mesenchymal transition [J] . Lu Dan-Hua, Yang Jiang, Gao Li-Kun, Oncology reports . 2019,第2期

机译：赖氨酸去甲基酶2A通过调节PI3K途径和逆转上皮间充质转换来促进卵巢癌的进展
4. The analysis of the PI3K/AKT pathway in human ovarian cancer with a combination of genomic and genetic approaches. [D] . Huang, Jia. 2006

机译：结合基因组学和遗传学方法分析人卵巢癌中的PI3K / AKT途径。
5. Inhibition of PI3K/Akt/mTOR signaling pathway alleviates ovarian cancer chemoresistance through reversing epithelial-mesenchymal transition and decreasing cancer stem cell marker expression [O] . Junli Deng, Xupeng Bai, Xiaojie Feng, 2019

机译：PI3K / Akt / mTOR信号通路的抑制通过逆转上皮-间质转化和减少癌症干细胞标志物的表达来减轻卵巢癌的化学耐药性
6. YTHDF1 promotes hepatocellular carcinoma progression via activating PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition [O] . Xiangyuan Luo, Mengdie Cao, Fan Gao, 2021

机译：YTHDF1通过激活PI3K / AKT / MTOR信号通路和诱导上皮 - 间充质转换来促进肝细胞癌进展

gamma-Glutamyl cyclotransferase contributes to tumor progression in high grade serous ovarian cancer by regulating epithelial-mesenchymal transition via activating PI3K/AKT/mTOR pathway

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