<fc xmlns='http://www.wiley.com/namespaces/wiley'>A</fc>A <fc xmlns='http://www.wiley.com/namespaces/wiley'>P</fc>P arkinson's disease gene, <fc xmlns='http://www.wiley.com/namespaces/wiley'>DJ</fc>DJ ‐1, repairs brain injury through <fc xmlns='http://www.wiley.com/namespaces/wiley'>S</fc>S ox9 stabilization and astrogliosis

Choi Dong‐Joo; Eun Jin‐Hwa; Kim Byung Gon; Jou Ilo; Park Sang Myun; Joe Eun‐Hye

摘要

Abstract >Defects in repair of damaged brain accumulate injury and contribute to slow‐developing neurodegeneration. Here, we report that a deficiency of DJ‐1, a Parkinson's disease (PD) gene, delays repair of brain injury due to destabilization of Sox9, a positive regulator of astrogliosis. Stereotaxic injection of ATP into the brain striatum produces similar size of acute injury in wild‐type and DJ‐1‐knockout (KO) mice. However, recovery of the injury is delayed in KO mice, which is confirmed by 9.4T magnetic resonance imaging and tyrosine hydroxylase immunostaining. DJ‐1 regulates neurite outgrowth from damaged neurons in a non‐cell autonomous manner. In DJ‐1 KO brains and astrocytes, Sox9 protein levels are decreased due to enhanced ubiquitination, resulting in defects in astrogliosis and glial cell‐derived neurotrophic factor/ brain‐derived neurotrophic factor expression in injured brain and astrocytes. These results indicate that DJ‐1 deficiency causes defects in astrocyte‐mediated repair of brain damage, which may contribute to the development of PD. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”> <title type =“main”>抽象</ title> >修复受损大脑的缺陷积累伤害有助于缓慢发展的神经变性。在这里，我们报告说，DJ-1的缺乏，帕金森病（Pd）基因，由于SOX9的稳定化而延迟了脑损伤的修复，这是一系列分子射精的阳性调节因子。立体胶质注射ATP进入脑纹状体在野生型和DJ-1敲除（KO）小鼠中产生类似的急性损伤大小。然而，在KO小鼠中延迟损伤的恢复，其被9.4T磁共振成像和酪氨酸羟化酶免疫染色确认。 DJ-1以非细胞自主方式调节从受损神经元的神经突槽。在DJ-1 KO脑和星形胶质细胞中，由于增强的泛素化，SOX9蛋白水平降低，导致在受伤的大脑和星形胶质细胞中的星形射精和神经胶囊源性神经营养因子/脑衍生的神经营养因子/脑衍生的神经营养因子表达中的缺陷。这些结果表明，DJ-1缺陷导致星形胶质细胞介导的脑损伤修复的缺陷，这可能导致PD的发展。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" > 著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-23771/'>《Glia 》</a> <b style="margin: 0 2px;">|</b><span>2018年第2期</span><b style="margin: 0 2px;">|</b> <span>共14页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Choi Dong‐Joo&option=202" target="_blank" rel="nofollow">Choi Dong‐Joo;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Eun Jin‐Hwa&option=202" target="_blank" rel="nofollow">Eun Jin‐Hwa;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kim Byung Gon&option=202" target="_blank" rel="nofollow">Kim Byung Gon;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jou Ilo&option=202" target="_blank" rel="nofollow">Jou Ilo;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Park Sang Myun&option=202" target="_blank" rel="nofollow">Park Sang Myun;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Joe Eun‐Hye&option=202" target="_blank" rel="nofollow">Joe Eun‐Hye;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Neuroscience Graduate Program Department of Biomedical SciencesAjou University School of Medicine Worldcup‐ro 164Suwon Kyunggi‐do 16499 Korea;</p> <p>Neuroscience Graduate Program Department of Biomedical SciencesAjou University School of Medicine Worldcup‐ro 164Suwon Kyunggi‐do 16499 Korea;</p> <p>Neuroscience Graduate Program Department of Biomedical SciencesAjou University School of Medicine Worldcup‐ro 164Suwon Kyunggi‐do 16499 Korea;</p> <p>Neuroscience Graduate Program Department of Biomedical SciencesAjou University School of Medicine Worldcup‐ro 164Suwon Kyunggi‐do 16499 Korea;</p> <p>Neuroscience Graduate Program Department of Biomedical SciencesAjou University School of Medicine Worldcup‐ro 164Suwon Kyunggi‐do 16499 Korea;</p> <p>Neuroscience Graduate Program Department of Biomedical SciencesAjou University School of Medicine Worldcup‐ro 164Suwon Kyunggi‐do 16499 Korea;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li> <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span> <a href="https://www.zhangqiaokeyan.com/clc/200.html" title="神经病学与精神病学">神经病学与精神病学 ;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=astrogliosis&option=203" rel="nofollow">astrogliosis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=brain repair&option=203" rel="nofollow">brain repair;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=DJ‐1&option=203" rel="nofollow">DJ‐1;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Parkinson's disease&option=203" rel="nofollow">Parkinson's disease;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sox9&option=203" rel="nofollow">Sox9;</a> </p> <div class="translation"> 机译：星形症;脑修复;DJ-1;帕金森病;SOX9; 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AA PP arkinson's disease gene, DJDJ ‐1, repairs brain injury through SS ox9 stabilization and astrogliosis

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