USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1 alpha/USP22 positive feedback loop upon TP53 inactivation

Ling Sunbin; Shan Qiaonan; Zhan Qifan; Ye Qianwei; Liu Peng; Xu Shengjun; He Xin; Ma Jian; Xiang Jiajia; Jiang Guangjiang; Wen Xue; Feng Zijie; Wu Yuan; Feng Tingting; Xu Li; Chen Kangchen; Zhang Xuanyu; Wei Rongli; Zhang Chenzhi; Cen Beini; Xie Haiyang; Song Penghong; Liu Jimin; Zheng Shusen; Xu Xiao

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USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1 alpha/USP22 positive feedback loop upon TP53 inactivation

机译：USP22通过HIF1α/ USP22阳性反馈回路促进缺氧诱导的肝细胞癌茎干，在TP53灭活时

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Objective We aimed to elucidate the mutual regulation mechanism of ubiquitin-specific protease 22 (USP22) and hypoxia inducible factor-1 alpha (HIF1 alpha), and the mechanism they promote the stemness of hepatocellular carcinoma (HCC) cells under hypoxic conditions.

机译：目的我们旨在阐明遍犯特异性蛋白酶22（USP22）和缺氧诱导因子-1α（HIF1α）的相互调节机制，以及它们在缺氧条件下促进肝细胞癌（HCC）细胞茎的机制。

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来源
《Gut: Journal of the British Society of Gastroenterology》 |2020年第7期|共13页
作者
Ling Sunbin; Shan Qiaonan; Zhan Qifan; Ye Qianwei; Liu Peng; Xu Shengjun; He Xin; Ma Jian; Xiang Jiajia; Jiang Guangjiang; Wen Xue; Feng Zijie; Wu Yuan; Feng Tingting; Xu Li; Chen Kangchen; Zhang Xuanyu; Wei Rongli; Zhang Chenzhi; Cen Beini; Xie Haiyang; Song Penghong; Liu Jimin; Zheng Shusen; Xu Xiao;
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作者单位

Zhejiang Univ Affiliated Hosp 1 Sch Med Dept Hepatobiliary &

Pancreat Surg Hangzhou 310003;

Zhejiang Univ Affiliated Hosp 1 Sch Med Dept Hepatobiliary &

Pancreat Surg Hangzhou 310003;

Zhejiang Univ Affiliated Hosp 1 Sch Med Dept Hepatobiliary &

Pancreat Surg Hangzhou 310003;

Zhejiang Univ Affiliated Hosp 1 Sch Med Dept Hepatobiliary &

Pancreat Surg Hangzhou 310003;

Zhejiang Univ Affiliated Hosp 1 Sch Med Dept Hepatobiliary &

Pancreat Surg Hangzhou 310003;

Zhejiang Univ Affiliated Hosp 1 Sch Med Dept Hepatobiliary &

Pancreat Surg Hangzhou 310003;

Univ Penn Perelman Sch Med Abramson Family Canc Res Inst Dept Canc Biol 421 Curie Blvd;

Univ Penn Perelman Sch Med Abramson Family Canc Res Inst Dept Canc Biol 421 Curie Blvd;

Zhejiang Univ Minist Educ Coll Chem &

Biol Engn Ctr Bionanoengn Hangzhou 310027 Zhejiang;

Zhejiang Univ Affiliated Hosp 1 Sch Med Dept Hepatobiliary &

Pancreat Surg Hangzhou 310003;

Zhejiang Univ Affiliated Hosp 1 Sch Med Dept Pathol Hangzhou 310003 Zhejiang Peoples R China;

Univ Penn Perelman Sch Med Abramson Family Canc Res Inst Dept Canc Biol 421 Curie Blvd;

Univ Penn Perelman Sch Med Abramson Family Canc Res Inst Dept Canc Biol 421 Curie Blvd;

Zhejiang Univ Affiliated Hosp 1 Sch Med Dept Hepatobiliary &

Pancreat Surg Hangzhou 310003;

Zhejiang Univ Affiliated Hosp 1 Sch Med Dept Hepatobiliary &

Pancreat Surg Hangzhou 310003;

Zhejiang Univ Affiliated Hosp 1 Sch Med Dept Hepatobiliary &

Pancreat Surg Hangzhou 310003;

Zhejiang Univ Affiliated Hosp 1 Sch Med Dept Hepatobiliary &

Pancreat Surg Hangzhou 310003;

Zhejiang Univ Affiliated Hosp 1 Sch Med Dept Hepatobiliary &

Pancreat Surg Hangzhou 310003;

Zhejiang Univ Affiliated Hosp 1 Sch Med Dept Hepatobiliary &

Pancreat Surg Hangzhou 310003;

CAMS NHC Key Lab Combined Multiorgan Transplantat Hangzhou 310003 Zhejiang Peoples R China;

CAMS NHC Key Lab Combined Multiorgan Transplantat Hangzhou 310003 Zhejiang Peoples R China;

CAMS NHC Key Lab Combined Multiorgan Transplantat Hangzhou 310003 Zhejiang Peoples R China;

McMaster Univ Dept Pathol &

Mol Med Fac Hlth Sci Hamilton ON L8J 0B4 Canada;

Zhejiang Univ Affiliated Hosp 1 Sch Med Dept Hepatobiliary &

Pancreat Surg Hangzhou 310003;

Zhejiang Univ Affiliated Hosp 1 Sch Med Dept Hepatobiliary &

Pancreat Surg Hangzhou 310003;

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原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
关键词
USP22; HIF1 alpha; hepatocellular carcinoma; cancer stemness;

机译：USP22;HIF1α;肝细胞癌;癌症茎;

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专利

1. USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1 alpha/USP22 positive feedback loop upon TP53 inactivation [J] . Ling Sunbin, Shan Qiaonan, Zhan Qifan, Gut: Journal of the British Society of Gastroenterology . 2020,第7期

机译：USP22通过HIF1α/ USP22阳性反馈回路促进缺氧诱导的肝细胞癌茎干，在TP53灭活时
2. HIF1 regulates WSB-1 expression to promote hypoxia-induced chemoresistance in hepatocellular carcinoma cells [J] . TongY., LiQ.-G., XingT.-Y., FEBS letters. . 2013,第16期

机译：HIF1调节WSB-1表达以促进缺氧诱导的肝癌细胞化学耐药性
3. USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway [J] . Sunbin Ling, Jie Li, Qiaonan Shan, Molecular oncology. . 2017,第6期

机译：USP22通过SIRT1 / AKT / MRP1信号通路介导肝细胞癌的多药耐药性
4. Alpha-fetoprotein Epitope Peptide Promoted the Proliferation of Primary Hepatocellular Carcinoma Cells [C] . Huanping Lin, Xiaoping Wang, Bing Xu, International Conference on Materials Engineering and Information Technology Applications . 2015

机译：α-胎儿蛋白表位肽促进原发性肝细胞癌细胞的增殖
5. Hepatitis B X antigen promotes "stemness" in the pathogenesis of hepatocellular carcinoma. [D] . Friedman, Tiffany Ilene. 2012

机译：乙型肝炎X抗原在肝细胞癌的发病机理中促进“干性”。
6. Hepatocellular Carcinoma: Self‐Activated Cascade‐Responsive Sorafenib and USP22 shRNA Co‐Delivery System for Synergetic Hepatocellular Carcinoma Therapy (Adv. Sci. 5/2021) [O] . Shengjun Xu, Sunbin Ling, Qiaonan Shan, 2021

机译：肝细胞癌：用于协同肝细胞癌疗法的自激酶级联响应索拉非苯胺和USP22 ShRNA共递送系统（ADV。SCI。5/2021）
7. Self‐Activated Cascade‐Responsive Sorafenib and USP22 shRNA Co‐Delivery System for Synergetic Hepatocellular Carcinoma Therapy [O] . Shengjun Xu, Sunbin Ling, Qiaonan Shan, 2021

机译：用于协同肝细胞癌疗法的自激活级联响应索拉义和USP22 ShRNA共递送系统
8. POSITIVE-FEEDBACK CLOSED-LOOP POLES IN POSITIVE-NEGATIVE FEEDBACK CONTROL SYSTEMS [R] . John Paul Hyde, E. E. 1963

机译：正负反馈控制系统中的正反馈闭环极点

USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1 alpha/USP22 positive feedback loop upon TP53 inactivation

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