Prediction of clinical outcomes in Crohn's disease by using confocal laser endomicroscopy: results from a prospective multicenter study

Tontini Gian Eugenio; Mudter Jonas; Vieth Michael; Guenther Claudia; Milani Valentina; Atreya Raja; Rath Timo; Nagel Andreas; Hatem Giorgia; Sturniolo Giacomo Carlo; Vecchi Maurizio; Neurath Markus F.; Galle Peter R.; Buda Andrea; Neumann Helmut

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Prediction of clinical outcomes in Crohn's disease by using confocal laser endomicroscopy: results from a prospective multicenter study

机译：使用共聚焦激光端瘤通过共聚焦激光诊断方法预测克罗恩病的临床结果：潜在多中心研究的结果

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Background and Aims: Assessment of prognostic factors in patients with Crohn's disease (CD) is of pivotal importance for early intervention and "treat-to-target" strategies. Confocal laser endomicroscopy (CLE) enables on-demand in vivo characterization of mucosal inflammatory and architectural changes during endoscopy. We prospectively assessed the value of CLE for prediction of clinical outcome parameters in CD.

机译：背景和目标：评估克罗恩病（CD）患者的预后因素是关键的重视早期干预和“对待目标”策略。共聚焦激光子宫内膜镜（CLE）能够在内窥镜检查期间体内表征粘膜炎症和建筑变化。我们预期评估CLE以预测CD中临床结果参数的价值。

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《Gastrointestinal Endoscopy》 |2018年第6期|共13页
作者
Tontini Gian Eugenio; Mudter Jonas; Vieth Michael; Guenther Claudia; Milani Valentina; Atreya Raja; Rath Timo; Nagel Andreas; Hatem Giorgia; Sturniolo Giacomo Carlo; Vecchi Maurizio; Neurath Markus F.; Galle Peter R.; Buda Andrea; Neumann Helmut;
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作者单位

Univ Erlangen Nurnberg Dept Med 1 Erlangen Germany;

Univ Erlangen Nurnberg Dept Med 1 Erlangen Germany;

Klinikum Bayreuth Inst Pathol Bayreuth Germany;

Univ Erlangen Nurnberg Dept Med 1 Erlangen Germany;

IRCCS Policlin San Donato San Donato Milanese Italy;

Univ Erlangen Nurnberg Dept Med 1 Erlangen Germany;

Univ Erlangen Nurnberg Dept Med 1 Erlangen Germany;

Univ Erlangen Nurnberg Dept Med 1 Erlangen Germany;

Univ Padua Dept Surg Oncol &

Gastroenterol Sci Padua Italy;

Univ Padua Dept Surg Oncol &

Gastroenterol Sci Padua Italy;

IRCCS Policlin San Donato Gastroenterol &

Digest Endoscopy Unit San Donato Milanese Italy;

Univ Erlangen Nurnberg Dept Med 1 Erlangen Germany;

Univ Med Ctr Mainz Med Dept 1 Mainz Germany;

Univ Padua Dept Surg Oncol &

Gastroenterol Sci Padua Italy;

Univ Erlangen Nurnberg Dept Med 1 Erlangen Germany;

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正文语种 eng
中图分类消化系及腹部疾病;
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1. Prediction of clinical outcomes in Crohn's disease by using confocal laser endomicroscopy: results from a prospective multicenter study [J] . Tontini Gian Eugenio, Mudter Jonas, Vieth Michael, Gastrointestinal Endoscopy . 2018,第6期

机译：使用共聚焦激光端瘤通过共聚焦激光诊断方法预测克罗恩病的临床结果：潜在多中心研究的结果
2. Real-time diagnosis of Barrett's esophagus: a prospective, multicenter study comparing confocal laser endomicroscopy with conventional histology for the identification of intestinal metaplasia in new users [J] . Cory Richardson, Paul Colavita, Christy Dunst, Surgical Endoscopy . 2019,第5期

机译：Barrett食管的实时诊断：一种预期的多中心研究比较了共聚焦激光子宫内容学与常规组织学中的常规组织学鉴定新用户
3. Needle-based confocal laser endomicroscopy of pancreatic cystic lesions: a prospective multicenter validation study in patients with definite diagnosis [J] . Napoleon Bertrand, Palazzo Maxime, Lemaistre Anne-Isabelle, Endoscopy: Journal for Clinical Use Biopsy and Technique . 2019,第9期

机译：胰腺囊性病变的针对基于针的共聚焦激光子宫内膜：确定诊断患者的前瞻性多中心验证研究
4. The In-depth quantitative proteomic and phosphoproteomic study of clinical sera derived from the Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) cohort: The quest for potential prediction biomarkers of pharmacologic effic acy [C] . Roumeliotis T.I., Zeidan B., Vougas K., American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：临床血清的深入定量蛋白质组学和磷蛋白蛋白酶研究源自散发性患者与遗传性乳腺癌（POSH）癌症的前瞻性研究（POSH）队列：寻求药理学效应射频的潜在预测生物标志物
5. Confocal laser endomicroscopy for Barrett's esophagus and gastroesophageal reflux disease. [D] . Dunbar, Kerry Brandt. 2012

机译：共聚焦激光内窥镜检查巴雷特食管和胃食管反流病。
6. Outcome of probe-based confocal laser endomicroscopy (pCLE) during endoscopic retrograde cholangiopancreatography: A single-center prospective study in 45 patients [O] . Johannes-Matthias Löhr, Ragnar Lönnebro, Serena Stigliano, 2015

机译：内镜逆行胰胆管造影术中基于探针的共聚焦激光内窥镜检查（pCLE）的结果：45位患者的单中心前瞻性研究
7. MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1. [O] . Upasana Tayal, Alexandros Kallifatidis, P. Garg, 2016

机译：在使用新的扩张型心肌病的患者缓和EPOSTERS1385Longitudinal应变评估加速DENSE sequence1407Simultaneous T1和T2与CABIRIA心脏定量：在4维流动的加速算法初始临床experience1423Head对头比较CMR1502Left心室功能和尺寸由混合心脏正电子发射断层摄影术评价 - 磁性共振：由两个modalities1510Left庭派生左室射血分数和心室体积的个体间的比较，在1.5和3特斯拉评估心血管磁共振 - 免费的年龄和性别effects1514Comparison呼吸心脏MRI径向技术标准的多屏气电影SSFP CMR技术的LV卷和Function1536Self-导航自由呼吸各向同性3D整个心脏相位敏感反转恢复磁共振导航仪没有检测右Ventricu心肌infarction1547Assessment的评估拉尔菌株使用心肌变形恢复半自动技术：初步经验和正常Values1586Tissue跟踪心肌变形分析和预测左室重构急性心肌infarction1589Investigating策略优化31P MRS临床心脏在3T：初始Results1620Quantitative标准的先天缺失的诊断心包心脏磁Resonance1632Widespread组织损伤急性心肌梗死时：证据先进CMR relaxometry1322Computed CT冠状动脉成像与压力心脏磁共振对症的管理吻合血管患者：成本效益研究（战略研究）1339Comparison低与高剂量钆布醇在1.5特斯拉晚钆增强成像的临床可行性，在中间型地贫心脏并发症的预测study1347Multi参数心脏核磁共振的前瞻性德穆尔心血管磁共振的ticenter Study1461Prognostic价值衍生心肌纤维化指标在住院的急性期CMR的心脏移植recipients1523The作用：改变基于CMR-paradigms1542Preoperative比分预测缺血性心脏衰竭patients1555Excellent响应速度外科左心室重建心脏再同步化后心室反应治疗与磁共振imaging1626The ECG导引作为心脏磁共振成像致心律失常性基板的在ST段抬高心肌infarction1340Pathological在风险评估经历在3.0T CMR T1映射的室性早搏contractions1649Comparison和血管造影APPROACH分数区域消融患者的预测左束支传导疾病的患者与非缺血性心肌病相关因素：心血管磁共振study1342Myocardial重塑和纤维化nonischaemic扩张型心肌病：在从在由心血管磁性resonance1622Persistent心肌炎症评估肥厚型心肌病的纤维化和收缩功能障碍之间心血管磁性resonance1411The协会由于心肌内出血景点在再灌注STEMI为先导，以不利的LV重塑 - 从低的多参数mapping1566Semiquantitative分析和高的b值DWI的见解为在心脏MRI检测冠状动脉疾病急性myocarditis1567Value在结节性硬化症complex1578Papillary肌肉初诊收缩期Dysfunction1570Usefulness心脏磁共振检测心肌水肿提供进一步的深入了解肥大心脏：心血管磁共振study1627Diagnostic和CMR定时的临床意义（早期与晚）患者肌钙蛋白阳性的急性冠脉综合征和通畅的冠状动脉：表1。

Prediction of clinical outcomes in Crohn's disease by using confocal laser endomicroscopy: results from a prospective multicenter study

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