Cytomegalovirus persistence and T-cell immunosenescence in people aged fifty and older: A systematic review

摘要

Introduction: Immunosenescence is the age-related deterioration of immunocompetence which is reflected in a poorer response to new antigens. This process is characterized by decreases in naive T cells and increases in memory T cells. The highly prevalent beta-herpesvirus cytomegalovirus (CMV) is thought to enhance T-cell immunosenescence. The aim of this study was to perform a systematic review on the current evidence regarding the relation between CMV-infection and immunosenescence in Western people aged fifty years and older.