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首页> 外文期刊>Experimental & Molecular Pathology >Early experience with formalin-fixed paraffin-embedded (FFPE) based commercial clinical genomic profiling of gliomas-robust and informative with caveats
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Early experience with formalin-fixed paraffin-embedded (FFPE) based commercial clinical genomic profiling of gliomas-robust and informative with caveats

机译：早期经验与福尔马林固定的石蜡嵌入式（FFPE）基于Gliomas的商业临床基因组分析 - 坚固且信息丰富的警告

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摘要

Background: Commercial targeted genomic profiling with next generation sequencing using formalin-fixed paraffin embedded (FFPE) tissue has recently entered into clinical use for diagnosis and for the guiding of therapy. However, there is limited independent data regarding the accuracy or robustness of commercial genomic profiling in gliomas.
机译：背景：最近使用福尔马林固定的石蜡包埋（FFPE）组织的靶向序列的商业靶向基因组分布已进入临床用途进行诊断和治疗的指导。 然而，有限的独立数据有关Gliomas商业基因组分析的准确性或稳健性的独立数据。

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  • 作者

    Movassaghi Masoud; Shabihkhani Maryam; Hojat Seyed A.; Williams Ryan R.; Chung Lawrance K.; Im Kyuseok; Lucey Gregory M.; Wei Bowen; Mareninov Sergey; Wang Michael W.; Ng Denise W.; Tashjian Randy S.; Magaki Shino; Perez-Rosendahl Mari; Yang Isaac; Khanlou Negar; Vinters Harry V.; Liau Linda M.; Nghiemphu Phioanh L.; Lai Albert; Cloughesy Timothy F.; Yong William H.;

  • 作者单位

    Univ Calif Los Angeles David Geffen Sch Med Dept Pathol &

    Lab Med Div Neuropathol Los Angeles;

    Univ Calif Los Angeles David Geffen Sch Med Dept Pathol &

    Lab Med Div Neuropathol Los Angeles;

    Univ Calif Los Angeles David Geffen Sch Med Dept Pathol &

    Lab Med Div Neuropathol Los Angeles;

    Univ Calif Los Angeles David Geffen Sch Med Dept Pathol &

    Lab Med Div Neuropathol Los Angeles;

    Univ Calif Los Angeles David Geffen Sch Med Dept Neurosurg Los Angeles CA 90095 USA;

    Univ Calif Los Angeles David Geffen Sch Med Dept Pathol &

    Lab Med Div Neuropathol Los Angeles;

    Univ Calif Los Angeles David Geffen Sch Med Dept Pathol &

    Lab Med Div Neuropathol Los Angeles;

    Univ Calif Los Angeles David Geffen Sch Med Dept Pathol &

    Lab Med Div Neuropathol Los Angeles;

    Univ Calif Los Angeles David Geffen Sch Med Dept Pathol &

    Lab Med Div Neuropathol Los Angeles;

    Univ Calif Los Angeles David Geffen Sch Med Dept Pathol &

    Lab Med Div Neuropathol Los Angeles;

    Univ Calif Los Angeles David Geffen Sch Med Dept Pathol &

    Lab Med Div Neuropathol Los Angeles;

    Univ Calif Los Angeles David Geffen Sch Med Dept Pathol &

    Lab Med Div Neuropathol Los Angeles;

    Univ Calif Los Angeles David Geffen Sch Med Dept Pathol &

    Lab Med Div Neuropathol Los Angeles;

    Univ Calif Los Angeles David Geffen Sch Med Dept Pathol &

    Lab Med Div Neuropathol Los Angeles;

    Univ Calif Los Angeles David Geffen Sch Med Dept Neurosurg Los Angeles CA 90095 USA;

    Univ Calif Los Angeles David Geffen Sch Med Dept Pathol &

    Lab Med Div Neuropathol Los Angeles;

    Univ Calif Los Angeles David Geffen Sch Med Dept Pathol &

    Lab Med Div Neuropathol Los Angeles;

    Univ Calif Los Angeles David Geffen Sch Med Dept Neurosurg Los Angeles CA 90095 USA;

    Univ Calif Los Angeles David Geffen Sch Med Dept Neurol Los Angeles CA 90095 USA;

    Univ Calif Los Angeles David Geffen Sch Med Dept Neurol Los Angeles CA 90095 USA;

    Univ Calif Los Angeles David Geffen Sch Med Dept Neurol Los Angeles CA 90095 USA;

    Univ Calif Los Angeles David Geffen Sch Med Dept Pathol &

    Lab Med Div Neuropathol Los Angeles;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 病理学;
  • 关键词

    Genomic profiling; Glioma; GBM; Exome profiling; Foundation medicine;

    机译：基因组分析;GLIOMA;GBM;exome分析;基础医学;

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