How close are we to implementing a genetic risk score for coronary heart disease?

Beaney Katherine; Drenos Fotios; Humphries Steve E.

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How close are we to implementing a genetic risk score for coronary heart disease?

机译：我们如何为冠心病实施遗传风险分数？

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Introduction: Genome-wide association meta-analysis have now identified more than 150 loci where common variants (SNPs) are significantly associated with coronary heart disease (CHD) and CHD end points.

机译：介绍：基因组 - 范围协会Meta分析现已识别出超过150个基因座，其中常见的变体（SNP）与冠心病（CHD）和CHD终点显着相关。

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《Expert Review of Molecular Diagnostics》 |2017年第12期|共11页
作者
Beaney Katherine; Drenos Fotios; Humphries Steve E.;
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作者单位

UCL Inst Cardiovasc Sci BHF Labs Ctr Cardiovasc Genet London England;

UCL Inst Cardiovasc Sci BHF Labs Ctr Cardiovasc Genet London England;

UCL Inst Cardiovasc Sci BHF Labs Ctr Cardiovasc Genet London England;

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原文格式 PDF
正文语种 eng
中图分类诊断学;
关键词
Genome wide association studies; classical risk factors; genetic risk score; algorithm; coronary heart disease;

机译：基因组宽协会研究;古典风险因素;遗传风险得分;算法;冠心病;

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1. How close are we to implementing a genetic risk score for coronary heart disease? [J] . Beaney Katherine, Drenos Fotios, Humphries Steve E. Expert Review of Molecular Diagnostics . 2017,第7a12期

机译：我们如何为冠心病实施遗传风险分数？
2. Prediction of Coronary Heart Disease Risk using a Genetic Risk Score: The Atherosclerosis Risk in Communities Study [J] . Alanna C. Morrison1 Lance A. Bare2 Lloyd E. Chambless3 Stephen G. Ellis4 Mary Malloy5 John P. Kane5 James S. Pankow6 James J. Devlin2 James T. Willerson7 and Eric Boerwinkle17 American Journal of Epidemiology . 2007,第1期

机译：使用遗传风险评分预测冠心病风险：社区研究中的动脉粥样硬化风险
3. Genetic predisposition to coronary heart disease and stroke using an additive genetic risk score: A population-based study in Greece [J] . YiannakourisN., KatsoulisM., DilisV., Atherosclerosis . 2012,第1期

机译：使用加成遗传风险评分对冠心病和中风的遗传易感性：希腊一项基于人群的研究
4. Application of Framingham Risk Score in the Assessment of Coronary Heart Disease (CHD) Risk in Qatar Petroleum's Staff [C] . Iqbal Mochtar, Rakhmat Subekti, Mahmood Abdulrahman Al Jaidah Society of Petroleum Engineers Middle East Health,Safety,Security and Environment Conference and Exhibition . 2010

机译：在卡塔尔石油职工冠心病（CHD）风险评估中的应用框架风险评分
5. Systematic review of genetic risk score in coronary heart disease and other diseases [D] . Sun, Jia 2009

机译：冠心病和其他疾病的遗传风险评分系统评价
6. A genetic risk score based on direct associations with coronary heart disease improves coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC) but not in the Rotterdam and Framingham Offspring Studies [O] . Ariel Brautbar, Lisa A. Pompeii, Abbas Dehghan, -1

机译：基于冠心病直接关联的遗传风险分数提高了冠心病风险预测社区（ARIC）的动脉粥样硬化风险但在鹿特丹和弗拉姆汉后代研究
7. Prediction of Coronary Heart Disease Risk using a Genetic Risk Score: The Atherosclerosis Risk in Communities Study [O] . Alanna C. Morrison, Lance A. Bare, Lloyd E. Chambless, 2007

机译：使用遗传风险评分预测冠心病风险：社区研究的动脉粥样硬化风险

How close are we to implementing a genetic risk score for coronary heart disease?

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