Altered anatomical connections of associative and limbic cortico-basal-ganglia circuits in obsessive-compulsive disorder

摘要

Background: Current neurocognitive models suppose dysfunctions of associative and limbic cortico-basal ganglia circuits to be at the core of obsessive-compulsive disorder (OCD). As little is known about the state of underlying anatomical connections, we investigated whether these connections were reduced and/or not properly organised in OCD patients compared to control.