Stromal Gene Expression is Predictive for Metastatic Primary Prostate Cancer

Mo Fan; Lin Dong; Takhar Mandeep; Ramnarine Varune Rohan; Dong Xin; Bell Robert H.; Volik Stanislav V.; Wang Kendric; Xue Hui; Wang Yuwei; Haegert Anne; Anderson Shawn; Brahmbhatt Sonal; Erho Nicholas; Wang Xinya; Gout Peter W.; Morris James; Karnes R. Jeffrey; Den Robert B.; Klein Eric A.; Schaeffer Edward M.; Ross Ashley; Ren Shancheng; Sahinalp S. Cenk; Li Yingrui; Xu Xun; Wang Jun; Wang Jian; Gleave Martin E.; Davicioni Elai; Sun Yinghao; Wang Yuzhuo; Collin Colin C.

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Stromal Gene Expression is Predictive for Metastatic Primary Prostate Cancer

机译：基因基因表达是转移性原发性前列腺癌的预测性

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Background: Clinical grading systems using clinical features alongside nomograms lack precision in guiding treatment decisions in prostate cancer (PCa). There is a critical need for identification of biomarkers that can more accurately stratify patients with primary PCa.

机译：背景：使用临床特征的临床分级系统，脊髓图缺乏精确的前列腺癌（PCA）的指导治疗决策。鉴定能够更准确地分析初级PCA患者的生物标志物的危急需要。

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来源
《European urology》 |2018年第4期|共9页
作者
Mo Fan; Lin Dong; Takhar Mandeep; Ramnarine Varune Rohan; Dong Xin; Bell Robert H.; Volik Stanislav V.; Wang Kendric; Xue Hui; Wang Yuwei; Haegert Anne; Anderson Shawn; Brahmbhatt Sonal; Erho Nicholas; Wang Xinya; Gout Peter W.; Morris James; Karnes R. Jeffrey; Den Robert B.; Klein Eric A.; Schaeffer Edward M.; Ross Ashley; Ren Shancheng; Sahinalp S. Cenk; Li Yingrui; Xu Xun; Wang Jun; Wang Jian; Gleave Martin E.; Davicioni Elai; Sun Yinghao; Wang Yuzhuo; Collin Colin C.;
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作者单位

Univ British Columbia Vancouver Prostate Ctr Vancouver BC Canada;

Univ British Columbia Vancouver Prostate Ctr Vancouver BC Canada;

GenomeDx Biosci Res &

Dev Vancouver BC Canada;

Univ British Columbia Vancouver Prostate Ctr Vancouver BC Canada;

BC Canc Agcy Dept Expt Therapeut Vancouver BC Canada;

Univ British Columbia Vancouver Prostate Ctr Vancouver BC Canada;

Univ British Columbia Vancouver Prostate Ctr Vancouver BC Canada;

Univ British Columbia Vancouver Prostate Ctr Vancouver BC Canada;

BC Canc Agcy Dept Expt Therapeut Vancouver BC Canada;

BC Canc Agcy Dept Expt Therapeut Vancouver BC Canada;

Univ British Columbia Vancouver Prostate Ctr Vancouver BC Canada;

Univ British Columbia Vancouver Prostate Ctr Vancouver BC Canada;

Univ British Columbia Vancouver Prostate Ctr Vancouver BC Canada;

GenomeDx Biosci Res &

Dev Vancouver BC Canada;

Univ British Columbia Vancouver Prostate Ctr Vancouver BC Canada;

BC Canc Agcy Dept Expt Therapeut Vancouver BC Canada;

BC Canc Agcy Dept Radiat Oncol Vancouver BC Canada;

Mayo Clin Coll Med Dept Urol Rochester MN USA;

Thomas Jefferson Univ Sidney Kimmel Med Coll Dept Radiat Oncol Philadelphia PA 19107 USA;

Cleveland Clin Glickman Urol &

Kidney Inst Cleveland OH 44106 USA;

Johns Hopkins Univ Hosp James Buchanan Brady Urol Inst Dept Urol Dept Oncol Baltimore MD 21287;

Johns Hopkins Univ Hosp James Buchanan Brady Urol Inst Dept Urol Dept Oncol Baltimore MD 21287;

Second Mil Med Univ Shanghai Changhai Hosp Dept Urol Shanghai Peoples R China;

Simon Fraser Univ Sch Comp Sci Burnaby BC Canada;

BGI Shenzhen Shenzhen Peoples R China;

BGI Shenzhen Shenzhen Peoples R China;

BGI Shenzhen Shenzhen Peoples R China;

BGI Shenzhen Shenzhen Peoples R China;

Univ British Columbia Vancouver Prostate Ctr Vancouver BC Canada;

GenomeDx Biosci Res &

Dev Vancouver BC Canada;

Second Mil Med Univ Shanghai Changhai Hosp Dept Urol Shanghai Peoples R China;

Univ British Columbia Vancouver Prostate Ctr Vancouver BC Canada;

Univ British Columbia Vancouver Prostate Ctr Vancouver BC Canada;

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原文格式 PDF
正文语种 eng
中图分类泌尿科学（泌尿生殖系疾病）;
关键词
Stromal gene; Prostate cancer metastasis; Prognostic biomarkers; Genomic profiling; RNA sequencing;

机译：基因;前列腺癌转移;预后生物标志物;基因组分析;RNA测序;

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1. 前列腺癌印记基因表达的特殊变化一前列腺癌发展和表观遗传调控的预示 [J] . Teodora Ribarska, Klaus-Marius Bastian, Annemarie Koch, 亚洲男性学杂志：英文版 . 2012,第003期
2. Re: Stromal Gene Expression is Predictive for Metastatic Primary Prostate Cancer [J] . Dong Liang, Pienta Kenneth J. European urology . 2018,第3期

机译：Re：基质基因表达是转移性原发性前列腺癌的预测性
3. A Metastatic Biology Gene Expression Assay to Predict the Risk of Distant Metastases in Patients With Localized Prostate Cancer Treated With Primary Radical Treatment [J] . Jain S., Lyons C., Walker S., International Journal of Radiation Oncology, Biology, Physics . 2017,第2Suppla期

机译：转移性生物学基因表达测定以预测患有初级自由基治疗局部前列腺癌患者远处转移的风险
4. Gene expression panel predicts metastatic‐lethal prostate cancer outcomes in men diagnosed with clinically localized prostate cancer [J] . Rohina Rubicz, Shanshan Zhao, Jonathan L. Wright, Molecular oncology. . 2017,第2期

机译：基因表达小组预测诊断为临床局限性前列腺癌的男性的转移致死性前列腺癌结局
5. Predicting Tumor Locations in Prostate Cancer Tissue Using Gene Expression [C] . Osama Hamzeh, Abedalrhman Alkhateeb, Luis Rueda International work-conference on bioinformatics and biomedical engineering . 2018

机译：使用基因表达预测前列腺癌组织中的肿瘤位置
6. Effects of 1 alpha,25-dihydroxyvitamin D3 and its analogs in cancer-associated hypercalcemia in vivo and in vitro, and in normal prostate epithelial and stromal primary cell cultures. [D] . Trakarnpaibul-Kunakornsawat, Sunee. 2001

机译：1 alpha，25-dihydroxyvitamin D3及其类似物在体内和体外以及正常前列腺上皮和基质原代细胞培养物中与癌症相关的高钙血症的作用。
7. Stromal Gene Expression is Predictive for Metastatic Primary Prostate Cancer [O] . Fan Mo, Dong Lin, Mandeep Takhar, -1

机译：基质基因表达可预测转移性原发性前列腺癌
8. Stromal Gene Expression is Predictive for Metastatic Primary Prostate Cancer [O] . Fan Mo, Dong Lin, Mandeep Takhar, 2018

机译：基质基因表达是转移性原发性前列腺癌的预测性

Stromal Gene Expression is Predictive for Metastatic Primary Prostate Cancer

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