Co-clinical Analysis of a Genetically Engineered Mouse Model and Human Prostate Cancer Reveals Significance of NKX3.1 Expression for Response to 5 alpha-reductase Inhibition

摘要

Background: Although men on active surveillance for prostate cancer (PCa) may benefit from intervention with 5 alpha-reductase inhibitors (5-ARIs), it has not been resolved whether 5-ARIs are effective for delaying disease progression and, if so, whether specific patients are more likely to benefit.