Urinary Protein Biomarker Database: A Useful Tool for Biomarker Discovery

摘要

An open-access biomarker database offers a convenient tool for researchers to acquire existing knowledge about proteins and diseases by simply querying its Web site. Biologists can use the biomarker database to assess the confidence and disease specificity of their own research results by cross-study comparison, and bioinformaticians can use it to discover new relationships between diseases and proteins by reanalyzing data via new strategies. This chapter introduces the urinary protein biomarker database, a manually curated database that aim to collect all studies of urinary protein biomarkers from published literature. In the current stage, this database includes very few disease-specific biomarker candidates that have been reported by multiple studies, reflecting current status in the field of urinary biomarker discovery. We believe that this situation will be improved with the development of technologies and accumulation of data, and a more complete and precise biomarker database will play more important role in future studies.