Exploring the clonal evolution of CD133/aldehyde-dehydrogenase-1 (ALDH1)-positive cancer stem-like cells from primary to recurrent high-grade serous ovarian cancer (HGSOC). A study of the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) Consortium

Ruscito Ilary; Castillo-Tong Dan Cacsire; Vergote Ignace; Ignat Iulia; Stanske Mandy; Vanderstichele Adriaan; Ganapathi Ram N.; Glajzer Jacek; Kulbe Hagen; Trillsch Fabian; Mustea Alexander; Kreuzinger Caroline; Panici Pierluigi Benedetti; Gourley Charlie; Gabra Hani; Kessler Mirjana; Sehouli Jalid; Darb-Esfahani Silvia; Braicu Elena Ioana

首页> 外文期刊>European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) >Exploring the clonal evolution of CD133/aldehyde-dehydrogenase-1 (ALDH1)-positive cancer stem-like cells from primary to recurrent high-grade serous ovarian cancer (HGSOC). A study of the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) Consortium

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Exploring the clonal evolution of CD133/aldehyde-dehydrogenase-1 (ALDH1)-positive cancer stem-like cells from primary to recurrent high-grade serous ovarian cancer (HGSOC). A study of the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) Consortium

机译：探索CD133 /醛 - 脱氢酶-1（ALDH1） - 阳性癌症状细胞的克隆演化从初发于经常性高级浆液癌（HGSOC）。卵巢癌治疗 - 创新模型的研究延长生存（八层）财团

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Background: High-grade serous ovarian cancer (HGSOC) causes 80% of all ovarian cancer (OC) deaths. In this setting, the role of cancer stem-like cells (CSCs) is still unclear. In particular, the evolution of CSC biomarkers from primary (pOC) to recurrent (rOC) HGSOCs is unknown. Aim of this study was to investigate changes in CD133 and aldehyde dehydrogenase-1 (ALDH1) CSC biomarker expression in pOC and rOC HGSOCs.

机译：背景：高级浆液卵巢癌（HGSOC）导致所有卵巢癌的80％（OC）死亡。在这种环境中，癌症干细胞（CSCs）的作用尚不清楚。特别地，来自原发性（POC）至复发性（ROC）Hgsocs的CSC生物标志物的演变是未知的。本研究的目的是研究POC和ROC HGSOC中CD133和醛脱氢酶-1（ALDH1）CSC生物标志物表达的变化。

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来源
《European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)》 |2017年第2017期|共12页
作者
Ruscito Ilary; Castillo-Tong Dan Cacsire; Vergote Ignace; Ignat Iulia; Stanske Mandy; Vanderstichele Adriaan; Ganapathi Ram N.; Glajzer Jacek; Kulbe Hagen; Trillsch Fabian; Mustea Alexander; Kreuzinger Caroline; Panici Pierluigi Benedetti; Gourley Charlie; Gabra Hani; Kessler Mirjana; Sehouli Jalid; Darb-Esfahani Silvia; Braicu Elena Ioana;
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作者单位

Charite Univ Med Berlin Dept Gynecol European Competence Ctr Ovarian Canc Campus Virchow;

Med Univ Vienna Ctr Comprehens Canc Dept Obstet &

Gynecol Waehringer Guertel 18-20 A-1090;

Katholieke Univ Leuven Div Gynaecol Oncol Leuven Canc Inst Dept Gynaecol &

Obstet Univ;

Charite Univ Med Berlin Dept Gynecol European Competence Ctr Ovarian Canc Campus Virchow;

Charite Inst Pathol Campus Mitte Berlin Germany;

Katholieke Univ Leuven Div Gynaecol Oncol Leuven Canc Inst Dept Gynaecol &

Obstet Univ;

Carolinas HealthCare Syst Levine Canc Inst Dept Canc Pharmacol Charlotte NC USA;

Charite Univ Med Berlin Dept Gynecol European Competence Ctr Ovarian Canc Campus Virchow;

Charite Univ Med Berlin Dept Gynecol European Competence Ctr Ovarian Canc Campus Virchow;

Univ Munich Dept Gynecol &

Obstet Marchioninistr 15 Munich Germany;

Univ Med Greifswald Dept Gynecol &

Obstet Greifswald Germany;

Med Univ Vienna Ctr Comprehens Canc Dept Obstet &

Gynecol Waehringer Guertel 18-20 A-1090;

Sapienza Univ Rome Dept Gynecol Obstet &

Urol Rome Italy;

Univ Edinburgh Canc Res UK Ctr Nicola Murray Ctr Ovarian Canc Res MRC IGMM Western Gen Hosp;

Imperial Coll London Dept Surg &

Canc Ovarian Canc Action Res Ctr London England;

Max Planck Inst Infect Biol Dept Mol Biol Berlin Germany;

Charite Univ Med Berlin Dept Gynecol European Competence Ctr Ovarian Canc Campus Virchow;

Charite Inst Pathol Campus Mitte Berlin Germany;

Charite Univ Med Berlin Dept Gynecol European Competence Ctr Ovarian Canc Campus Virchow;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Ovarian cancer; CD133; ALDH1; Aldehyde dehydrogenase-1; Cancer stem-like cell; BRCA; Prognosis; Survival;

机译：卵巢癌;CD133;Aldh1;醛脱氢酶-1;癌症干细胞;BRCA;预后;生存;

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专利

1. Exploring the clonal evolution of CD133/aldehyde-dehydrogenase-1 (ALDH1)-positive cancer stem-like cells from primary to recurrent high-grade serous ovarian cancer (HGSOC). A study of the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) Consortium [J] . Ruscito Ilary, Castillo-Tong Dan Cacsire, Vergote Ignace, European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2017,第期

机译：探索CD133 /醛 - 脱氢酶-1（ALDH1） - 阳性癌症状细胞的克隆演化从初发于经常性高级浆液癌（HGSOC）。卵巢癌治疗 - 创新模型的研究延长生存（八层）财团
2. Clonal Evolution of TP53 c.375+1GA Mutation in Pre- and Post- Neo-Adjuvant Chemotherapy (NACT) Tumor Samples in High-Grade Serous Ovarian Cancer (HGSOC) [J] . Marica Garziera, Erika Cecchin, Giorgio Giorda, Cells . 2019,第10期

机译：TP53 C.375 + 1G的克隆演化>新辅助化疗（NACT）肿瘤样品中的突变（NACT）肿瘤癌（HGSOC）
3. BRCA1 gene promoter methylation status in high-grade serous ovarian cancer patients - A study of the tumour Bank ovarian cancer (TOC) and ovarian cancer diagnosis consortium (OVCAD) [J] . RuscitoI., DimitrovaD., VasconcelosI., European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2014,第12期

机译：高度浆液性卵巢癌患者BRCA1基因启动子甲基化状态-肿瘤库卵巢癌（TOC）和卵巢癌诊断协会（OVCAD）的研究
4. CD133-positive cancer stem-like cells ablated by gold nanorod-mediated near-infrared laser treatment [C] . Peng Ching-An, Wang Chung-Hao 2011 IEEE 4th International Nanoelectronics Conference . 2011

机译：金纳米棒介导的近红外激光治疗消融CD133阳性癌症干细胞
5. Characterization of Precancerous Mutations in Ulcerative Colitis-Associated Colorectal Cancer and High-Grade Serous Ovarian Cancer via Duplex Sequencing [D] . Baker, Kathryn Terese 2018

机译：溃疡性结肠炎相关大肠癌和高级别浆液性卵巢癌癌前突变的双重测序表征。
6. Characterisation of tumour microvessel density during progression of high-grade serous ovarian cancer: clinico-pathological impact (an OCTIPS Consortium study). [O] . Ilary Ruscito, Dan Cacsire Castillo-Tong, Ignace Vergote, 2018

机译：高级别浆液性卵巢癌进展过程中肿瘤微血管密度的特征：临床病理影响（OCTIPS联盟研究）。
7. Exploring the clonal evolution of CD133/aldehyde-dehydrogenase-1 (ALDH1)-positive cancer stem-like cells from primary to recurrent high-grade serous ovarian cancer (HGSOC). A study of the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) Consortium. [O] . Ruscito, I, Cacsire Castillo-Tong, D, Vergote, I, 2017

机译：探索CD133 /醛脱氢酶-1（ALDH1）阳性癌症干样细胞从原发性到复发性高级别浆液性卵巢癌（HGSOC）的克隆进化。卵巢癌治疗创新模型延长生存期（OCTIPS）联盟的研究。

Exploring the clonal evolution of CD133/aldehyde-dehydrogenase-1 (ALDH1)-positive cancer stem-like cells from primary to recurrent high-grade serous ovarian cancer (HGSOC). A study of the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) Consortium

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