P-402: Effect of sit-to-stand exercises combined with protein-rich oral supplementation in older persons: the OPEN study

摘要

Introduction: Residents living in nursing homes (NH) are often undernourished and physically inactive, contributing to sarcopenia and frailty. This study aimed to investigate the impact of sit-to-stand exercises (STS) combined with a protein-rich oral nutritional supplement (ONS) on physical function and nutritional status. Methods: A cluster-randomized clinical trial was performed in eight NH. The participants were randomized into an intervention group (IG) or a standard-of-care control group (CG), (n = 60/group). The IG target was a combination of STS (4 times/day) and ONS (2 servings/day) for 12 weeks. The participants were 75 + years and able to rise from a seated position. The 30 s chair stand test (30sCST) was the primary outcome. Secondary outcomes were balance, walking speed, ADL dependence, nutritional status and body composition. Inferential statistics including logistic regression models were applied. Results: 102 residents completed the study. No improvement in physical function assessments was observed. Body weight increased significantly (2.05 ± 3.5 kg, p = 0.013). Residents with high adherence to the intervention, i.e. 21 out of 52 with at least 40% compliance to the combined intervention, increased their fat free mass (2.12 kg (0.13, 4.26 IQR), p = 0.007). Logistic regression analyses indicated that the Odds Ratio for maintained/improved 30sCST was 3.5 (CI 1.1, 10.9, p = 0.034) among the residents with high adherence compared to the CG. Conclusions: Twelve-week intervention of daily STS combined with ONS in NH residents did not improve physical function but did increase body weight. High adherence to the intervention was associated with maintained or improved physical function and improved nutritional status.