P-462: Healthcare-associated infections (HAIs) and antimicrobial use (AMU) in Greek long-term care facilities (LTCFs)

摘要

Objective: As healthcare-associated infections (HAIs) seem to emerge in the ageing population, an attempt to estimate the total prevalence of HAIs and antimicrobial use (AMU) in the majority of Greek long-term care facilities (LTCFs) was conducted in 2016-2017. Methods: Thirteen LTCFs in Crete took part in the survey. Data were based on two questionnaires, an institutional and a residential one, and collected on a single day for each LTCF by a designated physician. Results: 812 residents living 24 h a day in the LTCF, being presented at 8:00 AM and not being discharged on the day of the PPS met the eligibility criteria for inclusion. Mean size of occupied beds were 63.2. Prevalence of HAIs and AMU was 6.4% and 6.03%, respectively. 52 HAIs were recorded with RTIs (49.9%) and UTIs (28.8%) being more frequent. Most commonly prescribed antibacterials were beta-lactams (Jo1C) (28.3%), penicillins (Jo1C) (21.6%) and quino-lones (Jo1 M) (18.3%). Moreover, as independent risk factors for HAIs and AMU statistical analysis identified recent hospital admission (p < 0.001), OR (95% CI) [3.136 (1.610-6.112)] vs (p < 0.001), OR (95% CI) [3.424 (1.669-1.723), faecal and/or urinary incontinence, (p = 0.010), OR (95% CI) [3.703 (1.376-9.968)] vs (p = 0.004), OR (95% CI) [4.996 (1.676-14.890)], respectively, and male gender (p = 0.002), OR (95% CI) [2.807 (1.472-5.352)] only for AMU. Conclusion: The prevalence of HAIs in LTCFs shows a trend to increase compared to previous data from Greece as well as Europe, whereas AMU seems to be steady. Moreover, Greek LTCFs lack of specific evidence-based guidelines regarding prudent antibiotic use making their formation mandatory.