Risk assessment for ovarian cancer

摘要

Introduction: Ovarian cancer (OC) is the most common malignancy among women and epidemiological data report the trends in OC incidence to steadily increase. Objectives: The aim of the study was to analyze selected, non-genetic risk factors for OC, and to design a mathematical model and a risk assessment tool for it. Materials and Methods: The study included healthy women with no focal changes in the breast and ovaries (control group) and patients with OC (study group). A total of 1346 women, aged from 18 to 80, were included in the study. An original questionnaire, designed especially for the purpose of the study and comprising of 40 questions, was used as one of the evaluation tools. All respondents underwent a clinical psychological evaluation. Results: Risk Assessment for Ovarian Cancer Chart (RAFOCC) was designed on the basis of the odds ratio (OR) analysis for individual parameters and revealed that women who scored 31.5 points on a scale from 0 to 72, with a 72% test sensitivity (95% confidence interval (CI) 0.656-0.783) and 75% specificity (95% CI 0.718-0.770), face a statistically significantly increased risk for OC. Conclusions: RAFOCC is a useful screening tool for identifying women with increased risk for OC. Women who scored 31.5 points face a statistically significantly increased risk for OC. High-risk patients should be offered timely medical care and undergo further diagnostic testing.