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首页> 外文期刊>European journal of gynaecological oncology >Primary neuroendocrine carcinoma of the endometrium - a case report
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Primary neuroendocrine carcinoma of the endometrium - a case report

机译:子宫内膜的原发性神经内分泌癌 - 案例报告

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摘要

Neuroendocrine carcinomas (NEC) of the female genital tract are uncommon and aggressive. The authors report the single case of primary NEC of the endometrium at their institution. A 54-year-old female presented with post-menopausal bleeding and gross ascites. Histology from endometrial curettings revealed large cell NEC of the endometrium. The patient underwent total hysterectomy, bilateral salpingo-oophorectomy, pelvic and para-aortic lymphadenectomy, and omentectomy with adjuvant chemotherapy for Stage 1A NEC of the endometrium. The disease recurred in the left iliac bone, with invasion to the left iliacus and gluteal muscles, which was treated with radiotherapy. Repeat imaging showed progressive disease with development of skin metastases over the groin region despite treatment. Palliative chemotherapy was commenced. The patient passed away 26 months after her initial surgery. This case highlights the aggressiveness of NEC, with a poor outcome despite an early stage at diagnosis, and the challenges in diagnosis and management of such a rare carcinoma.
机译:女性生殖道的神经内分泌癌(NEC)是罕见和侵略性的。作者报告了他们所机构的子宫内膜的单一案例。一名54岁女性介绍了绝经后出血和腹水。子宫内膜卷曲的组织学揭示了子宫内膜的大细胞NEC。患者接受了总子宫切除术,双侧Salpingo-Oophorectomy,盆腔和β-主动脉淋巴结切除术,含有辅助化疗的子宫内膜阶段1A的辅助化疗。该疾病在左髂骨中重复,侵袭左侧髂骨和贫肌,用放射治疗治疗。尽管治疗,重复成像显示出腹股沟区域的皮肤转移的发展。姑息化疗开始。患者在她的初始手术后26个月过世。这种情况突出了NEC的攻击性,尽管诊断早期阶段,但诊断和管理这种稀有癌的挑战仍然存在较差的结果。

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