The basic helix–loop–helix transcription factor Crf1 is required for development and pathogenicity of the rice blast fungus by regulating carbohydrate and lipid metabolism

Cao Huijuan; Huang Pengyun; Yan Yuxin; Shi Yongkai; Dong Bo; Liu Xiaohong; Ye Lidan; Lin Fucheng; Lu Jianping

摘要

Summary > Pyricularia oryzae is a plant pathogen causing rice blast, a serious disease spreading in cultivated rice globally. Transcription factors play important regulatory roles in fungal development and pathogenicity. Here, we characterized the biological functions of Crf1, a basic helix–loop–helix (bHLH) transcription factor, in the development and pathogenicity of P. oryzae with functional genetics, molecular and biochemical approaches. We found that CRF1 is necessary for virulence and plays an indispensable role in the regulation of carbohydrate and lipid metabolism in P. oryzae . Deletion of CRF1 led to defects in utilization of lipids, ethanol, glycerol and L‐arabinose, and down‐regulation of many important genes in lipolysis, β ‐oxidation, gluconeogenesis, as well as glycerol and arabinose metabolism. CRF1 is also essential for peroxisome and vacuole function, and conidial cell death during appressorium formation. The appressorium turgor, penetration ability and virulence in Δ crf1 were restored by supplementation of exogenous glucose. The virulence of Crf1 mutant was also recovered by adding exogenous D‐xylose, but not by addition of ethanol, pyruvate, leucine or L‐arabinose. These data showed that Crf1 plays an important role in the complex regulatory network of carbohydrate and lipid metabolism that governs fungal development and pathogenicity. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <title type =“main”>摘要</ title> > <i > Pyricularia Oryzae </ i>是一种植物病原体，导致水稻爆炸，在全球耕种稻米蔓延的严重疾病。转录因子在真菌发育和致病性中发挥着重要的调节作用。在这里，我们表征了CRF1的生物学功能，基本螺旋环 - 螺旋（BHLH）转录因子，在 p的发育和致病性中。 oryzae </ i>具有功能性遗传学，分子和生化方法。我们发现 CRF1 </ i>对于毒力是必要的，并且在碳水化合物和脂质代谢的调节中起不可或缺的作用，在 p中。 oryzae </ i>。缺失 CRF1 </ i>在利用脂质，乙醇，甘油和L-阿拉伯糖的利用中导致缺陷，以及脂解中许多重要基因的下调，<iβ</ i> - 氧化，葡糖生成，以及甘油和阿拉伯糖代谢。 CRF1也对过氧化物组织和液泡功能也是必不可少的，并且在灌注过程中的结合细胞死亡。通过补充外源性葡萄糖来恢复α CRF1 / i>中的血压Turgor，渗透能力和毒力。通过添加外源D-木糖，还通过加入乙醇，丙酮酸，亮氨酸或L-阿拉伯糖来回收CRF1突变体的毒力。这些数据表明，CRF1在碳水化合物和脂质代谢的复杂调节网络中起重要作用，治理真菌发育和致病性。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-22868/'>《Environmental microbiology》</a> <b style="margin: 0 2px;">|</b><span>2018年第9期</span><b style="margin: 0 2px;">|</b><span>共15页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cao Huijuan&option=202" target="_blank" rel="nofollow">Cao Huijuan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Huang Pengyun&option=202" target="_blank" rel="nofollow">Huang Pengyun;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yan Yuxin&option=202" target="_blank" rel="nofollow">Yan Yuxin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shi Yongkai&option=202" target="_blank" rel="nofollow">Shi Yongkai;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dong Bo&option=202" target="_blank" rel="nofollow">Dong Bo;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Xiaohong&option=202" target="_blank" rel="nofollow">Liu Xiaohong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ye Lidan&option=202" target="_blank" rel="nofollow">Ye Lidan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lin Fucheng&option=202" target="_blank" rel="nofollow">Lin Fucheng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lu Jianping&option=202" target="_blank" rel="nofollow">Lu Jianping;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>State Key Laboratory for Rice BiologyCollege of Life Sciences Zhejiang UniversityHangzhou 310058 Zhejiang Province China;</p> <p>State Key Laboratory for Rice BiologyCollege of Life Sciences Zhejiang UniversityHangzhou 310058 Zhejiang Province China;</p> <p>State Key Laboratory for Rice BiologyCollege of Life Sciences Zhejiang UniversityHangzhou 310058 Zhejiang Province China;</p> <p>State Key Laboratory for Rice BiologyCollege of Life Sciences Zhejiang UniversityHangzhou 310058 Zhejiang Province China;</p> <p>Institute of Virology and Biotechnology Zhejiang Academy of Agricultural SciencesHangzhou 310021 Zhejiang Province China;</p> <p>State Key Laboratory for Rice BiologyInstitute of Biotechnology Zhejiang UniversityHangzhou 310058 Zhejiang Province China;</p> <p>Institute of Bioengineering College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310027 China;</p> <p>State Key Laboratory for Rice BiologyInstitute of Biotechnology Zhejiang UniversityHangzhou 310058 Zhejiang Province China;</p> <p>State Key Laboratory for Rice BiologyCollege of Life Sciences Zhejiang UniversityHangzhou 310058 Zhejiang Province China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/183.html" title="微生物学">微生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> 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