Within‐host evolution <i xmlns='http://www.wiley.com/namespaces/wiley'>versusversus immigration as a determinant of <i xmlns='http://www.wiley.com/namespaces/wiley'>Escherichia coliEscherichia coli diversity in the human gastrointestinal tract

Dixit Ojas V. A.; OBrien Claire L.; Pavli Paul; Gordon David M.

摘要

Summary > When a human host harbors two or more strains of Escherichia coli , the second strain is more likely to be a member of the same phylogroup rather than a different phylogroup. This outcome may be the consequence of a within host evolution event or an independent immigration/establishment event. To determine the relative importance of these two events in determining E. coli diversity in a host, a collection of multiple E. coli isolates recovered from each of 67 patients undergoing colonoscopies was used. Whole genome sequence data were available for one example of every REP‐fingerprint type identified in a patient. Sequence type (ST) and single‐nucleotide polymorphism (SNP) analyses revealed that 83% of strains observed in the host population were a consequence of immigration/establishment events. Restricting the analysis to hosts harboring two or more strains belonging to the same phylogroup revealed that in about half of these cases, the presence of a second strain belonging to the same phylogroup was the consequence of an independent immigration/establishment event. Thus, the results of this study show that despite hosts being exposed to a diversity of E. coli via their food, factors related to the host also determine what E. coli strains succeed in establishing. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <title type =“main”>摘要</ title> >时人宿主Harbors两种或更多种大肠杆菌的菌株，第二菌株更可能是相同文学组的构件而不是不同的晶类。这一结果可能是宿主进化事件或独立移民/建立事件内的后果。为了确定这两个事件在确定 e时的相对重要性。 Coli </ i>在主机中的多样性，多个 e的集合。使用从67名患者接受结肠镜检查的患者中回收的COLI </ i>分离物。全基因组序列数据可用于患者中识别的每种REP指纹类型的一个示例。序列类型（ST）和单核苷酸多态性（SNP）分析表明，在宿主人群中观察到的83％的菌株是移民/建立事件的结果。将分析限制对窝藏属于同一植物组的两种或更多种菌株的宿主显示，在这些情况的约一半中，属于同一植物组的第二种应变是独立移民/建立事件的结果。因此，本研究的结果表明，尽管宿主暴露于 e的多样性。 Coli </ i>通过他们的食物，与宿主有关的因素也确定了什么 e。 Coli </ i>菌株成功建立。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-22868/'>《Environmental microbiology》</a> <b style="margin: 0 2px;">|</b><span>2018年第3期</span><b style="margin: 0 2px;">|</b><span>共9页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dixit Ojas V. A.&option=202" target="_blank" rel="nofollow">Dixit Ojas V. A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=OBrien Claire L.&option=202" target="_blank" rel="nofollow">OBrien Claire L.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pavli Paul&option=202" target="_blank" rel="nofollow">Pavli Paul;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gordon David M.&option=202" target="_blank" rel="nofollow">Gordon David M.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Ecology and Evolution Research School of BiologyThe Australian National University 116 Daley Road ActonACT 2601 Australia;</p> <p>Medical School Australian National UniversityCanberra ACT Australia;</p> <p>Medical School Australian National UniversityCanberra ACT Australia;</p> <p>Ecology and Evolution Research School of BiologyThe Australian National University 116 Daley Road ActonACT 2601 Australia;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/183.html" title="微生物学">微生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023229266.html">Within‐host evolution <i xmlns="http://www.wiley.com/namespaces/wiley">versusversus immigration as a determinant of <i xmlns="http://www.wiley.com/namespaces/wiley">Escherichia coliEscherichia coli diversity in the human gastrointestinal tract</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dixit Ojas V. 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Within‐host evolution versusversus immigration as a determinant of Escherichia coliEscherichia coli diversity in the human gastrointestinal tract

摘要