Gonadotropin replacement in male thalassemia major patients with arrested puberty and acquired hypogonadotropic hypogonadism (AAH): preliminary results and potential factors affecting induction of spermatogenesis

摘要

Although spontaneous fertility can occur in well-transfused and well-chelated patients, with β-thalassemia major (β-ΤΜ), the majority are sub fertile due to hypogonadotropic hypogonadism (HH), secondary to transfusional haemosiderosis [1]. Ιn several studies, 40 to 80% of β-ΤΜ patients reported to have arrested puberty, pubertal failure, sexual dysfunction, and infertility [1, 2].