Primary hyperparathyroidism in prostate cancer: guilty or not guilty?

摘要

Skeletal health is a clinically relevant issue in patients with prostate cancer (PC) [1-3]. Bone is the most common site of PC cell migration with up to 90% of patients with advanced disease having bone metastases [4] with potential negative impact on quality of life and survival [5]. Since the first description of the "seed and soil" hypothesis by Stephan Paget in 1889 [6], several cellular signaling pathways, cytokines, chemokines, and adhesion molecules have been identified as players of cross-talking between PC cells and bone [7] attempting to relate them either to metastases diagnosis or to patients' prognosis (as prognostic factors) or to response to therapy (as predictive factors) [8].