Three‐dimensional speckle tracking echocardiography–derived left atrial deformation analysis in acromegaly (Results from the MAGYAR MAGYAR ‐Path Study)

摘要

Introduction Acromegaly is a chronic and disfiguring hormonal disease caused by a benign growth hormone‐secreting pituitary adenoma in most of the cases. The objective of this study was to investigate three‐dimensional (3D) speckle tracking echocardiography (3 DSTE )‐derived left atrial ( LA ) volumetric and functional properties in patients with acromegaly. It was also examined whether the activity of acromegaly is associated with further alterations in these LA parameters. Methods A total of 23 patients with acromegaly were involved in this study. Due to inadequate image quality, 4 patients were excluded from the 3 DSTE analysis. The mean age of the remaining acromegalic subjects was 58.5?±?13.1?years (7?males). The control group consisted of 21 age‐ and gender‐matched healthy subjects (mean age 51.8?±?10.3?years, 10?males). Results Maximum (44.8?±?12.7?mL vs 78.7?±?25.4?mL, P ??.05), minimum (24.1?±?9.0?mL vs 44.5?±?15.5?mL, P ??.05), and preatrial contraction (35.5?±?11.2?mL vs 66.0?±?22.8?mL, P ??.05) LA volumes were significantly different between all acromegaly patients compared with controls. Increased peak global and mean segmental radial and 3D strains and decreased LA circumferential strain ( CS ) could be detected in all acromegaly patients as compared to healthy subjects. Significant correlation could be detected between insulin‐like growth factor 1 ( IGF ‐1) index and peak superior LA‐CS ( r ?=?.49, P ?=?.05) in acromegaly. Conclusion Acromegaly is associated with increased LA volumes and changes in LA functional properties.