Gadolinium Retention, Brain T1 Hyperintensity, and Endogenous Metals A Comparative Study of Macrocyclic Versus Linear Gadolinium Chelates in Renally Sensitized Rats

摘要

Objectives: This preclinical study was designed to compare gadolinium (Gd) brain uptake after repeated injections of a macrocyclic Gd-based contrast agent (GBCA) (gadoterate meglumine) or 2 linear GBCAs (L-GBCAs) (gadobenate dimeglumine or gadodiamide) on a translational model of moderate renal impairment in rats.