Differential expression of immune factor between patients with chronic prostatitis/chronic pelvic pain syndrome and the healthy volunteers

摘要

Abstract Purpose Immune mechanisms have been hypothesized to contribute to the development of CP/CPPS. In this study, we investigated the differential expression of immune factors between patients with CP/CPPS and healthy volunteers. Methods This study was registered in Australian New Zealand Clinical Trials Registry. Healthy volunteers and patients with CP/CPPS were enrolled in this study. The inclusion criteria for patients were below: (1) aged 18–45?years old; (2) prostatitis-related syndrome longer than 3?months; (3) normal routine urine culture and negative bacterial culture in prostatic fluid. Patients were further classified into two groups: types IIIA and IIIB CP/CPPS according to the results of EPS routine test. Serum immune markers include IgA, IgM, IgG, CD4_(+)and CD8_(+). Results There are total 23 CP/CPPS patients, including 12 type IIIB and 11 type IIIA. Relatively, there are 26 healthy volunteers. The serum levels of IgG were higher in CP/CPPS patients compared to healthy volunteers (1141.2?±?204.3 vs 1031.9?±?173.7?mg/L, p ?=?0.045), while the serum levels of CD8_(+)were lower in CP/CPPS patients compared to healthy volunteers (492.8?±?185.6 vs 640.0?±?246.8 cells/μL, p ?=?0.021). Furthermore, serum levels of IgG were higher in patients with IIIA CP/CPPS compared to those with IIIB (1244.3?±?151.6 vs 1054.3?±?209.3?mg/L, p ?=?0.023). Conclusions Differential levels of IgG and CD8_(+)between CPPS patients and healthy volunteers suggest a contributing role of immune mechanisms to the development of CP/CPPS; and IgG may play an important role in inflammatory CPPS. Clinical Study registration number ACTRN12613000792729.