Frequency and Duration Modulate Anticarcinogenic Effects of a Physical Training in the Colon

摘要

Physical exercise has proven protective against colon carcinogenesis. We sought to clarify whether the frequency and duration of physical training were key factors for its anticarcinogenic effects on the colon. Either sedentary or physically trained male Wistar rats (n = 82) were either exposed or not to the carcinogen dimethylhidra-zine (DMH). The first protocol investigated whether swimming for 60min in different frequencies modulates antipreneoplastic effects of physical training. Another protocol then explored whether the duration for training 5 times a week impacts on the development of colon preneo-plastic lesions. After 8 weeks, serum and colon samples were collected and analyzed afterwards.