Capillary alginate gel (Capgel (TM)) for the treatment of full-thickness dermal wounds in a hypoxic mouse model

摘要

In this study, capillary alginate gel (Capgel((TM))), a collagen and alginate based self-assembling biomaterial, was used as a cellular scaffold for the treatment of ischemic, full-thickness dermal wounds in mice. Capgel((TM)) was synthesized using copper sulfate to form the initial sol before rinsing and stabilizing the patent capillary structures with carbodiimide chemistry. This crosslinked hydrogel was then injected into ischemic, full-thickness dermal wounds and analyzed via histology after 7 and 10 days to assess wound contracture, granulation bed tissue and vascular structures. Capgel((TM)) showed good resorbability and was well-invested with infiltrating host cells and vascular structures during and after resorption.