Simulation of Ventilatory Responses to Dead Space and CO_2 Inhalation with Optimal Respiratory Control Model

摘要

Many experiments have been performed and differences have been observed in the ventilatory response to breathing with an imposed external dead space and inhalation of a fixed level of CO_2 in human subjects. One of the human respiratory control models which successfully demonstrate the ventilatory responses to chemical stimuli as well as muscular exercise was proposed earlier with optimality hypothesis. In this study, to verify the model behavior of the optimal chemical-mechanical respiratory control model, the ventilatory control under dead space loading and CO_2 inhalation were simulated. A LabVIEW based human respiratory control simulator and signal monitoring system based on the environment was implemented for simulation. The dead space volume was described with two distinct models, from Gary and Coon, and the effects on the ventilatory responses were investigated and compared with experimental findings.