Late miscarriage and preterm birth after treatment with clindamycin: a randomised consent design study according to Zelen.

摘要

The value of treating bacterial vaginosis (BV) in pregnancy remains controversial. Studies failing to show a beneficial outcome have been mainly those in which treatment has been late in pregnancy and/or the antibiotic has been metronidazole, which is inactive against many of the microbes associated with BV. Clindamycin has a much wider spectrum of activity. It seems relevant that studies in which a beneficial outcome has been seen have been mainly those with clindamycin given early. For example, Ugwumadu et al. demonstrated that treating BV, both symptomatic and asymptomatic, early in pregnancy with oral clindamycin reduced the combined rate of late miscarriage and preterm deliveries by three-fold.