Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study)

Welte Tobias; Dellinger R. Phillip; Ebelt Henning; Ferrer Miguel; Opal Steven M.; Singer Mervyn; Vincent Jean-Louis; Werdan Karl; Martin-Loeches Ignacio; Almirall Jordi; Artigas Antonio; Ignacio Ayestaran Jose; Nuding Sebastian; Ferrer Ricard; Sirgo Rodriguez Gonzalo; Shankar-Hari Manu; Alvarez-Lerma Francisco; Riessen Reimer; Sirvent Josep-Maria; Kluge Stefan; Zacharowski Kai; Bonastre Mora Juan; Lapp Harald; Woebker Gabriele; Achtzehn Ute; Brealey David; Kempa Axel; Sanchez Garcia Miguel; Brederlau Joerg; Kochanek Matthias; Reschreiter Henrik Peer; Wise Matthew P.; Belohradsky Bernd H.; Bobenhausen Iris; Dalken Benjamin; Dubovy Patrick; Langohr Patrick; Mayer Monika; Schuettrumpf Joerg; Wartenberg-Demand Andrea; Wippermann Ulrike; Wolf Daniele; Torres Antoni

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Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study)

机译：一种新型多克隆抗体制剂，严重社区获得的肺炎患者的疗效和安全性：随机，安慰剂控制，双盲，多中心，第二期试验（CIGMA研究）

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Purpose: The CIGMA study investigated a novel human polyclonal antibody preparation (trimodulin) containing similar to 23% immunoglobulin (Ig) M, similar to 21% IgA, and similar to 56% IgG as add-on therapy for patients with severe community-acquired pneumonia (sCAP).

机译：目的：CIGMA研究研究了含有类似于23％免疫球蛋白（IG）M的新型人多克隆抗体制剂（综合素），类似于21％IgA，并且类似于56％IgG作为严重社区获得的患者的加载疗法肺炎（湿湿）。

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来源
《Intensive care medicine》 |2018年第4期|共11页
作者
Welte Tobias; Dellinger R. Phillip; Ebelt Henning; Ferrer Miguel; Opal Steven M.; Singer Mervyn; Vincent Jean-Louis; Werdan Karl; Martin-Loeches Ignacio; Almirall Jordi; Artigas Antonio; Ignacio Ayestaran Jose; Nuding Sebastian; Ferrer Ricard; Sirgo Rodriguez Gonzalo; Shankar-Hari Manu; Alvarez-Lerma Francisco; Riessen Reimer; Sirvent Josep-Maria; Kluge Stefan; Zacharowski Kai; Bonastre Mora Juan; Lapp Harald; Woebker Gabriele; Achtzehn Ute; Brealey David; Kempa Axel; Sanchez Garcia Miguel; Brederlau Joerg; Kochanek Matthias; Reschreiter Henrik Peer; Wise Matthew P.; Belohradsky Bernd H.; Bobenhausen Iris; Dalken Benjamin; Dubovy Patrick; Langohr Patrick; Mayer Monika; Schuettrumpf Joerg; Wartenberg-Demand Andrea; Wippermann Ulrike; Wolf Daniele; Torres Antoni;
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作者单位

Hannover Med Sch Dept Pneumol Carl Neuberg Str 1 D-30625 Hannover Germany;

Rowan Univ Cooper Med Sch Dept Med Cooper Univ Hlth Care Camden NJ USA;

Univ Klinikum Halle Saale Klin &

Poliklin Innere Med 3 Halle Saale Germany;

Univ Barcelona Resp Inst Hosp Clin Barcelona Dept Pneumol IDIBAPS CibeRes CB06 06 0028;

Brown Univ Div Infect Dis Rhode Isl Hosp Alpert Med Sch Providence RI 02912 USA;

UCL Bloomsbury Inst Intens Care Med London England;

Univ Libre Bruxelles Erasme Univ Hosp Dept Intens Care Brussels Belgium;

Univ Klinikum Halle Saale Klin &

Poliklin Innere Med 3 Halle Saale Germany;

St James Hosp Trinity Ctr Hlth Sci Multidisciplinary Intens Care Res Org MICRO Wellc HRB Clin;

Univ Autonoma Barcelona Hosp Mataro Unitat Cures Intens Barcelona Spain;

Autonomous Univ Barcelona CIBER Enfermedades Respiratorias Crit Care Ctr Corporacio Sanitaria;

Hosp Univ Son Espases Unidad Cuidados Intensivos Palma De Mallorca Spain;

Univ Klinikum Halle Saale Klin &

Poliklin Innere Med 3 Halle Saale Germany;

Hosp Univ Mutua Terrassa SODIR VHIR Res Grp Barcelona Spain;

Rovira &

Virgili Univ Intens Care Unit Hosp Univ Joan 23 Inst Invest Sanitaria Pere Virgili;

Guys &

St Thomas NHS Fdn Trust Intens Care Med London England;

Hosp Mar Serv Med Intens Barcelona Spain;

Univ Klinikum Tubingen Internist Intensivstat Tubingen Germany;

Hosp U Girona Dr Josep Trueta Serv Med Intens Avinguda Franca Girona Spain;

Univ Klinikum Hamburg Eppendorf Klin Intensivmed Hamburg Germany;

Univ Klinikum Frankfurt Klin Anasthesiol Intensivmed &

Schmerztherapie Frankfurt Germany;

Hosp Univ &

Politecn La Fe Serv Cuidados Intensivos Adultos Valencia Spain;

Helios Klinikum Erfurt Med Klin Kardiol &

Intensivmed 3 Erfurt Germany;

Helios Univ Klinikum Wuppertal Klin Intensivmed Wuppertal Germany;

Klinikum Chemnitz gGmbH Innere Med Pneumol 4 Chemnitz Germany;

NHS Fdn Trust Univ Coll London Hosp Crit Care Unit NIHR Univ Coll London Hosp Biomed Res Ctr;

Katharinen Hosp Klin Allgemeine Innere Med Stuttgart Germany;

Hosp Clin San Carlos Serv Med Intens Madrid Spain;

Helios Klinikum Berlin Buch Klin Intensivmed Berlin Germany;

Univ Hosp Cologne Dept Internal Med Intens Care Unit &

Hemostasis Cologne Germany;

Poole Hosp NHS Fdn Trust Poole Dorset England;

Univ Hosp Wales Crit Care Unit Heath Pk Cardiff S Glam Wales;

Ludwig Maximilians Univ Munchen Univ Childrens Hosp Munich Munich Germany;

Biotest AG Dreieich Germany;

Biotest AG Dreieich Germany;

Biotest AG Dreieich Germany;

Biotest AG Dreieich Germany;

Biotest AG Dreieich Germany;

Biotest AG Dreieich Germany;

Biotest AG Dreieich Germany;

Biotest AG Dreieich Germany;

Biotest AG Dreieich Germany;

Univ Barcelona IDIBAPS Hosp Clin Servei Pneumol CIBERES Barcelona Spain;

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原文格式 PDF
正文语种 eng
中图分类护理学;
关键词
Trimodulin; Polyclonal antibody; Severe community-acquired pneumonia; Add-on therapy; Immunoglobulin M;

机译：葡萄糖蛋白;多克隆抗体;严重的群落获得的肺炎;附加治疗;免疫球蛋白m;

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机译：一种新型多克隆抗体制剂，严重社区获得的肺炎患者的疗效和安全性：随机，安慰剂控制，双盲，多中心，第二期试验（CIGMA研究）
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Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study)

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