After the recent high precision determinations of Vus and Vud, the first rowof theCKMmatrix shows more than 4s deviation from unitarity. Two possible scenarios beyond the StandardModel can be investigated in order to fill the gap. If a 4th non-sequential quark b (a vector-like weak isosinglet) participates in the mixing, with |Vub| 0.04, then its mass should be no more than 6 TeV or so. A different solution can come from the introduction of the gauge horizontal family symmetry SU(3) acting between the lepton families and spontaneously broken at the scale of about 6 TeV. Since the gauge bosons of this symmetry contribute to muon decay in interference with Standard Model, the Fermi constant is slightly smaller than the muon decay constant so that unitarity is recovered. Also the neutron lifetime problem, that is about 4s discrepancy between the neutron lifetimes measured in beam and trap experiments, is discussed in the light of the these determinations of the CKM matrix elements.
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