A Facile Synthesis and Molecular Docking for Anti-inflammatory Activity of 2-(4-Chlorobenzyl)-1-(2-(pyrrolidin-1-yl)ethyl)-1H-benzo[d]imidazol-5-amine and 2-(4-Chlorobenzyl)-1-((1-ethylpyrrolidin-2-yl)methyl)-1H-benzo[d]imidazol-5-amine

摘要

A simple and efficient method was developed for the synthesis of 2-(4-chlorobenzyl)-1-(2-(pyrrolidin-1-yl)ethyl)-1H-benzo [d] imidazol-5-amine 8a and 2-(4-chlorobenzyl)-1-((1-ethylpyrrolidin-2-yl)methyl)-1H-benzoglimidazol-5-amine 8b. The synthesized compounds were characterized by infrared, 1H-nuclear magnetic resonance and mass spectral analyses. Molecular docking of 5cox with both the ligands using docking server predicted both the compounds to be potential anti-inflammatory compounds.