Solubility Enhancement of Paroxetine Hydrochloride by Hydrotropy

摘要

The present work is focused to develop a novel technique for selecting hydrotropic agents to enhance the solubility of low soluble drug, paroxetine hydrochloride. Paroxetine hydrochloride was estimated using UV spectrophotometry at 293 nm and hydrotropic agents did not interfere with drug estimation. In order to elucidate the interaction, a UV spectrophotometric method was developed. As the concentration of the hydrotropic agent increased, the solubility of paroxetine hydrochloride increased linearly for nicotinamide, citric acid and tartaric acid at 25 degrees and 37 degrees. Neutralization by pH adjustment technique was employed with hydrotropic agents to prepare hydrotropes. Each hydrotrope was characterized by melting point, Fourier transform infrared spectroscopy, solubility and dissolution. The in vitro dissolution studies showed that paroxetine hydrochloride release was enhanced from the prepared hydrotropes ( 80%) in comparison to the pure drug (37%) in 40 min. In vitro dissolution studies of tablets prepared using hydrotropes demonstrated two times increase in drug release ( 88%) in comparison to the marketed tablets (56%) in 40 min.