Angiogenic factors combined with clinical risk factors to predict preterm pre-eclampsia in nulliparous women: A predictive test accuracy study

摘要

The SCOPE consortium report (September 2013) on the plasma biomarkers placental growth factor, soluble fms-like tyrosine kinase-1 and endoglin early in pregnancy for predicting preterm pre-eclampsia is the climax of a huge piece of work.However, the SCOPE study registration site defined the planned primary outcome as pre-eclampsia 'at any stage during pregnancy after recruitment until delivery or in the first 2 weeks after delivery'. It also denned a planned secondary outcome of 'early onset pre-eclampsia' defined as 'pre-eclampsia resulting in delivery at <34 weeks'.