Comparison Study of Blood Compatibility of an AMPS based Hydrogel with its Gold Nanoparticle Composite Hydrogel

摘要

A stimuli-sensitive Gold Nanoparticle Composite hydrogel has been prepared from Polyvinyl alcohol(PVA), 2-acrylamido-2-methylpropane sulfonic acid (AMPS) and acryl amide(AM) have been prepared by Citrate reduction method . The structure, morphology, thermal nature of hydrogel is investigated by FT-IR, SEM, and TGA respectively. The optical behavior of gold nanoparticle is studied by its UV-Vis analysis. The Swelling study shows that the water uptake property of the hydrogel is dependent on composition of polymer, pH and temperature of the medium. The in vitro blood compatibility of the hydrogel were determined in terms of blood clot formation, percentage of haemolysis and protein (bovine serum albumin, BSA) adsorption tests. The hydrogel prepared in this study might be useful in cell and tissue engineering applications.