Synthesis of Polysubstituted Pyridine Derivatives via Sequential AlCl3‐Catalyzed Condensation/Aza‐Wittig/Isomerization Reactions and a Study of their Antifungal Activities

Ren Zhi‐Lin; Su Lei; Cai Shuang; Lu Wen‐Ting; Qiao Yue; He Ping; Ding Ming‐Wu

摘要

Abstract > A facile approach to access polysubstituted pyridine derivatives starting from Baylis‐Hillman adducts is disclosed. The reactions proceeded smoothly by sequential AlCl <sub>3</sub> ‐catalyzed condensation/aza‐Wittig/isomerization reactions, leading to the target products at room temperature within 24?h in moderate to good yields. Furthermore, the final products were evaluated in mycelial growth tests against Pythium dissimile , Botryotinia fuckeliana and Zymoseptoria tritici and showed potential activities. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 公开了一种从Baylis-Hillman加合物开始的多助化吡啶衍生物的容易接近的方法。通过顺序ALCL平稳地进行了反应 <sub> 3 </ sub> - 催化凝结/ AZA-Wittig /异构化反应，在室温下在24μm温度下导致靶产物，中等至良好的产量。此外，最终产品在菌丝体生长测试中进行评估 Pythium disifile </ i> 那 Botryotinia fuckeliana </ i> 和 Zymoseptoria tritici </ i> 并显示出潜在的活动。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-19765/'>《Asian Journal of Organic Chemistry》</a> <b style="margin: 0 2px;">|</b><span>2019年第8期</span><b style="margin: 0 2px;">|</b><span>共4页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ren Zhi‐Lin&option=202" target="_blank" rel="nofollow">Ren Zhi‐Lin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Su Lei&option=202" target="_blank" rel="nofollow">Su Lei;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cai Shuang&option=202" target="_blank" rel="nofollow">Cai Shuang;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lu Wen‐Ting&option=202" target="_blank" rel="nofollow">Lu Wen‐Ting;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Qiao Yue&option=202" target="_blank" rel="nofollow">Qiao Yue;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=He Ping&option=202" target="_blank" rel="nofollow">He Ping;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ding Ming‐Wu&option=202" target="_blank" rel="nofollow">Ding Ming‐Wu;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>College of Chemical EngineeringHubei University of Arts and ScienceXiangyang 441053 Hubei Province P. R. of China;</p> <p>College of Chemical EngineeringHubei University of Arts and ScienceXiangyang 441053 Hubei Province P. R. of China;</p> <p>College of Chemical EngineeringHubei University of Arts and ScienceXiangyang 441053 Hubei Province P. R. of China;</p> <p>Key Laboratory of Pesticide &</p> <p>Chemical Biology of Ministry of EducationCentral China Normal UniversityWuhan 430079 P. R. China;</p> <p>College of Chemical EngineeringHubei University of Arts and ScienceXiangyang 441053 Hubei Province P. R. of China;</p> <p>College of Chemical EngineeringHubei University of Arts and ScienceXiangyang 441053 Hubei Province P. R. of China;</p> <p>Key Laboratory of Pesticide &</p> <p>Chemical Biology of Ministry of EducationCentral China Normal UniversityWuhan 430079 P. R. China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1184.html" title="有机化学">有机化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=antifungal&option=203" rel="nofollow">antifungal;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=aza-Wittig reaction&option=203" rel="nofollow">aza-Wittig reaction;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=isomerization&option=203" rel="nofollow">isomerization;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lewis acid&option=203" rel="nofollow">Lewis acid;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=nitrogen heterocycles&option=203" rel="nofollow">nitrogen heterocycles;</a> </p> <div class="translation"> 机译：抗真菌;AZA-Wittig反应;异构化;路易斯酸;氮杂环; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022773528.html">Synthesis of Polysubstituted Pyridine Derivatives via Sequential AlCl3‐Catalyzed Condensation/Aza‐Wittig/Isomerization Reactions and a Study of their Antifungal Activities</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ren Zhi‐Lin&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Ren Zhi‐Lin,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Su Lei&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Su Lei,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cai Shuang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Cai Shuang,</a> <a href="/journal-foreign-19765/" target="_blank" rel="nofollow" class="tuijian_authcolor">Asian Journal of Organic Chemistry .</a> <span>2019</span><span>,第8期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：通过顺序ALCL3催化缩合/ AZA-Wittig /异构化反应合成多助化吡啶衍生物及其抗真菌活性的研究</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704020416590.html">One-Pot Synthesis of Polysubstituted Imidazoles via Sequential Staudinger/aza-Wittig/Ag(I)-Catalyzed Cyclization/Isomerization</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xiong Jun&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Xiong Jun,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wei Xiao&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wei Xiao,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Zi-Ming&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Liu Zi-Ming,</a> <a href="/journal-foreign-30984/" target="_blank" rel="nofollow" class="tuijian_authcolor">The Journal of Organic Chemistry .</a> <span>2017</span><span>,第24期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：通过顺序富豪/ AZA-WITTIG / AG（I）通过顺序合成多助化咪唑的合成 - 催化环化/异构化</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704020414144.html">Synthesis of Polysubstituted Isoquinolines and Related Fused Pyridines from Alkenyl Boronic Esters via a Copper-Catalyzed Azidation/Aza-Wittig Condensation Sequence</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Vankudoth Jayaram&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Vankudoth Jayaram,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tailor Sridhar&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Tailor Sridhar,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gangavaram V. M. Sharma&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Gangavaram V. M. Sharma,</a> <a href="/journal-foreign-30984/" target="_blank" rel="nofollow" class="tuijian_authcolor">The Journal of Organic Chemistry .</a> <span>2018</span><span>,第2期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：通过铜催化的叠氮化/ AZA-Wittig缩合序列合成聚烯基硼态酯的二磺酸盐异喹啉及相关熔融吡啶</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-256383_thesis/0705010415545.html">SYNTHESIS OF 2-(2'-PIPERIDNYL)PYRIDINE DERIVATIVES AND THEIR USE AS LIGANDS IN ASYMMETRIC HENRY AND AZA-HENRY REACTIONS</a> <b>[C]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Artur Noole&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Artur Noole,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tonis Kanger&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Tonis Kanger </a> <a href="/conference-foreign-256383/" target="_blank" rel="nofollow" class="tuijian_authcolor">European Symposium on Organic Chemistry .</a> <span>2009</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：合成2-（2'-哌啶基）吡啶衍生物及其用作不对称亨利和AZA-HENRY反应中的配体的用途</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/02061274856.html">Design and synthesis of novel chiral arsines for asymmetric Wittig reactions and palladium-catalyzed asymmetric allylic alkylation and asymmetric Heck reactions.</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wu, Huafeng.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wu, Huafeng. </a> <span>2004</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：设计和合成用于不对称Wittig反应和钯催化的不对称烯丙基烷基化和不对称Heck反应的新型手性ral。</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/040003499214.html">One-pot sequential synthesis of isocyanates and urea derivatives via a microwave-assisted Staudinger–aza-Wittig reaction</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Diego Carnaroglio&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Diego Carnaroglio,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Katia Martina&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Katia Martina,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Giovanni Palmisano&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Giovanni Palmisano,</a> <span>2013</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：微波辅助Staudinger-Aza-Wittig反应一锅法连续合成异氰酸酯和尿素衍生物</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/0100070711498.html ">Suzuki-aza-Wittig, Suzuki-condensation and aza-Wittig-electrocyclic ring-closure tandem reactions for synthesis of fused nitrogen-containing ring systems</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gábor Krajsovszky&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Gábor Krajsovszky,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=László Károlyházy&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">László Károlyházy,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Petra Dunkel&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Petra Dunkel,</a> <span>2011</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：suzuki-aza-Wittig，suzuki-condensation和aza-Wittig-电环闭环串联反应合成稠合含氮环系</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_tianjin-chemical-industry_thesis/0201248561103.html">甲酚异构化催化剂的研制：甲酚在HCl—AlCl3上的异构化作用</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=穆瑞才&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 穆瑞才</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=崔春需&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,崔春需</a> <span> <a href="/journal-cn-9222/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 天津化工 </a> </span> <span> . 1994</span><span>,第001期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-applied-chemistry_thesis/0201272094798.html">磷酸二氢钾催化Yonemitsu缩合反应合成5-(3-吲哚基)-芳甲基-2,2-二甲基-1,3-二噁烷-4,6-二酮衍生物</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=吕成伟&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 吕成伟</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘妍杭&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,刘妍杭</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王佳晶&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王佳晶</a> <span> <a href="/journal-cn-54377/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 应用化学 </a> </span> <span> . 2015</span><span>,第012期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-catalysis_thesis/0201231576284.html">固载化AlCl3催化剂上α-蒎烯异构化反应</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=吴义辉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 吴义辉</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=田福平&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,田福平</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=贺民&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,贺民</a> <span> <a href="/journal-cn-28399/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 催化学报 </a> </span> <span> . 2011</span><span>,第007期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-xinjiang-university-natural-science-edition_thesis/0201248031184.html">水相Rh(COD)Cl2/BINAP催化二炔与腈2+2+2环加成反应合成吡啶衍生物</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=徐粉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 徐粉</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=康位粉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,康位粉</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=孟彦羽&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,孟彦羽</a> <span> <a href="/journal-cn-4517/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 新疆大学学报（自然科学版） </a> </span> <span> . 2016</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_guangdong-chemical-industry_thesis/0201246348519.html">N-丁基吡啶氯铝酸离子液体催化酰基化反应合成乙酰水杨酰胺的研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨晋安&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 杨晋安</a> <span> <a href="/journal-cn-9122/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 广东化工 </a> </span> <span> . 2015</span><span>,第016期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-19630_thesis/020222258887.html">四组分Ugi缩合反应合成1，2，3噻二唑衍生物及其生物活性</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=左翔&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 左翔</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=范志金&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,范志金</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=范志银&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,范志银</a> <span> <a href="/conference-cn-19630/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国化工学会农药专业委员会第十三届年会 </a> <span> <span> . 2008</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020312063972.html">基于钯催化碳-氢键活化反应合成咪唑并吡啶衍生物的研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王瀚旸&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王瀚旸</a> <span> . 2015</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120106544961.html">使用合成气转化催化剂和贵金属助催化的酸性沸石加氢裂化-加氢异构化催化剂将合成气转化成液体燃料的方法</a> <b>[P]</b> . <span> 中国专利： CN102365347A </span> <span> . 2012-02-29</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/061202771755.html">异构化催化剂组合物和异构化催化剂及其应用和制备方法</a> <b>[P]</b> . <span> 中国专利： CN105478159B </span> <span> . 2018.02.23</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130448223686.html">Homo-conjugated triene preparation in high yield, by sequential Wittig reactions of bis-ylid with two aldehyde components, useful in synthesis of highly unsaturated fatty acids, leukotrienes or pheromones</a> <b>[P]</b> . <span> 外国专利：  DE19923274A1 </span> <span> . 2000-11-23</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：通过双基与两个醛组分的连续Wittig反应，高产率制备均相共轭三烯，可用于合成高度不饱和脂肪酸，白三烯或信息素 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130409673198.html">Palladium/silver co-catalyzed tandem reactions synthesis of phenylacetophenone derivatives by oxabenzonorbornadienes with terminal alkynes and their anti-tumor or anti-cancer activities</a> <b>[P]</b> . <span> 外国专利：  US9783519B2 </span> <span> . 2017-10-10</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：氧杂苯并降冰片二烯与末端炔烃的钯/银共催化串联反应合成苯乙酮衍生物及其抗肿瘤或抗癌活性 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130409965591.html">PALLADIUM/SILVER CO-CATALYZED TANDEM REACTIONS SYNTHESIS OF PHENYLACETOPHENONE DERIVATIVES BY OXABENZONORBORNADIENES WITH TERMINAL ALKYNES AND THEIR ANTI-TUMOR OR ANTI-CANCER ACTIVITIES</a> <b>[P]</b> . <span> 外国专利：  US2016368890A1 </span> <span> . 2016-12-22</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：氧杂苯并硼氢化二烯与末端烷基的钯/银共催化串联反应合成苯乙酮衍生物及其抗肿瘤或抗癌活性 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704022773528','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: flex;margin-top: 69px;justify-content: space-between;"> <div class="no-sub" onclick="$('.journalsub-pop-up').hide()">暂不订阅</div> <div class="other-sub" onclick="continueSub('from=pc-detail')">继续订阅其他期刊</div> </div> </div> </div> <div class="right_btn"> <ul> <li class="gouwuche">  </li> <li class="yijian"> <a href="javascript:void(0);" onclick="link_analysis('/mycenter/auth/complaint.html',this)" title="意见反馈">意见反馈</a> </li> <li class="top"> <a href="javascript:scrollTo(0,0);" title="回到顶部">回到顶部</a> </li> <li class="shouye"> <a href="/" title="首页">回到首页</a> </li> </ul> </div> <div class="xllindexfooter"> <div class="xllindexfootercenter"> <div class="xllindexfooterleft left" > <div class="xllindexfooterleftli"> <ul> <li><a href="/about.html" title="关于掌桥">关于掌桥</a></li> <li><a href="/help/helpmap.html" title="资源导航">资源导航</a></li> <li><a href="/help/helpguide.html" title="新手指南">新手指南</a></li> <li><a href="/help/helpcenter.html" title="常见问题">常见问题</a></li> <li><a href="/sitemap.html" title="网站地图">网站地图</a></li> <li><a href="/help/helpcenter.html?type=9" title="版权声明">版权声明</a></li> </ul> </div> <div class="xllindexfooterleft"> <p class="xllindexfooterlefteamil">客服邮箱：kefu@zhangqiaokeyan.com</p> <div class="xllindexfooterlefttcp"> <div class="xllindexfooterpoliceiimg"></div> <div class="xllindexfooterpoliceispan"> <span>京公网安备：11010802029741号 </span> <span>ICP备案号：<a href="https://beian.miit.gov.cn" rel="nofollow" target="_blank" title="ICP备案号">京ICP备15016152号-6</a></span> <span>六维联合信息科技 (北京) 有限公司©版权所有</span> </div> </div> </div> </div> <div class="xllindexfooterright left"> <ul> <li> <p style="font-weight: bold;">客服微信</p> <div></div> </li> <li> <p style="font-weight: bold;">服务号</p> <div></div> </li> </ul> </div> </div> </div> <span id="0704022773528down" data-source="7," data-out-id="asQANcdo7yoRCN+JvZScBIeEctX3ZneadXXV40RbnR0XRYaryVIHLdq1hpH3WVMy," data-f-source-id="7" data-title="Synthesis of Polysubstituted Pyridine Derivatives via Sequential AlCl3‐Catalyzed Condensation/Aza‐Wittig/Isomerization Reactions and a Study of their Antifungal Activities" data-price="20" data-site-name="" data-transnum="24" style="display:none;"></span> <input type="hidden" value="4" id="sourcetype"> <input type="hidden" value="19765" id="journalid"> <input type="hidden" value="1" id="inyn_provide_service_level"> <input type="hidden" value="https://cdn.zhangqiaokeyan.com" id="imgcdn"> <input type="hidden" value="1" id="isdeatail"> <input type="hidden" value="" id="syyn_indexed_database"> <input type="hidden" value="" id="servicetype"> <input type="hidden" id="pagename" value="Synthesis of Polysubstituted Pyridine Derivatives via Sequential AlCl3‐Catalyzed Condensation/Aza‐Wittig/Isomerization Reactions and a Study of their Antifungal Activities"/> <input type="hidden" value="thesis_get_original" id="pageIdentification"> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery-1.12.4.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/lwlh_ajax.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zq.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/common.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery.cookie.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/top.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/login.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/down.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/search.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/newmail.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/searchtype.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/user/regist.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/detail.js?v=5.7.8"></script> <script type="text/javascript" src="https://www.zhangqiaokeyan.com/statistics/static/pagecollection.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/tj.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/sse.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/pushbaidu.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/history.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/util/cookie.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/weipu/weipu.js?v=5.7.8"></script> </body> <script> function kefu(customization) { var from = GetQueryString("from"); if (from == null || from == "") { from = "other"; } var url = getWxWorkQrCode(55, from, customization); if (url == "" || typeof url == 'undefined') { url = "https://wework.qpic.cn/wwpic/994838_0LUTS-VqR0quT1N_1675665967/0"; } tipDocGuidance(url, '人工辅助获取外文期刊材料'); } $(function(){ var weiPuStatus = getCookie('WeiPuStatus'); if(weiPuStatus){ tipWeiPuStatus(weiPuStatus); delCookie('WeiPuStatus'); } getFacetKeywordVoInId(); var sourcetype = $("#sourcetype").val(); var inyn_provide_service_level = $("#inyn_provide_service_level").val(); if((sourcetype ==1||sourcetype==4)&&inyn_provide_service_level!=4){ getJournal(); } }) </script> </html>