Combined Role of Type IX Collagen and Cartilage Oligomeric Matrix Protein in Cartilage Matrix Assembly Cartilage Oligomeric Matrix Protein Counteracts Type IX Collagen-Induced Limitation of Cartilage Collagen Fibril Growth in Mouse Chondrocyte Cultures

摘要

Objective. Defects in the assembly and composition of cartilage extracellular matrix are likely to result in impaired matrix integrity and increased susceptibility to cartilage degeneration. The aim of this study was to determine the functional interaction of the collagen fibril-associated proteins type IX collagen and cartilage oligomeric matrix protein (COMP) during cartilage matrix formation.