The DOT1L 2982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males

摘要

Osteoarthritis (OA) of the hip is a major cause of pain, disability and use of healthcare resources.1 Although OA is multifac-torial, it is known to have significant genetic contribution and a number of studies have attempted to dissect such contribution (see2 for review).The DOTH gene encodes the DOTl-like histone H3 methyl-transferaseis, a potentially dedicated enzyme for Wnt target gene activation in leukaemia recently shown to be associated with endochondral bone formation.