Down-regulation of PARP1 by miR-891b sensitizes human breast cancer cells to alkylating chemotherapeutic drugs

Xu Shujian; Zhao Cui; Jia Zhongming; Wang Xilong; Han Yong; Yang Zhenlin

首页> 外文期刊>Archives of gynecology and obstetrics. >Down-regulation of PARP1 by miR-891b sensitizes human breast cancer cells to alkylating chemotherapeutic drugs

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Down-regulation of PARP1 by miR-891b sensitizes human breast cancer cells to alkylating chemotherapeutic drugs

机译：MiR-891B的PARP1的下调使人乳腺癌细胞敏化为烷基化化学治疗药物

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摘要

Breast cancer is the most common invasive type of cancer among women. Role of different microRNAs (miRNAs) and poly(ADP-ribose) polymerases (PARPs) in breast cancer has been well established. This study aimed to explore the effects of miR-891b on sensitizing breast cancer cells to alkylating chemotherapeutic drugs through PARPs.

机译：乳腺癌是女性中最常见的侵入式癌症。乳腺癌中不同的微小RNA（miRNA）和聚（ADP-核糖）聚合酶（PARP）的作用已经得到了很好的成熟。本研究旨在探讨miR-891b对乳腺癌细胞敏感到烷基化化学治疗药物通过parps的影响。

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来源
《Archives of gynecology and obstetrics.》 |2017年第3期|共7页
作者
Xu Shujian; Zhao Cui; Jia Zhongming; Wang Xilong; Han Yong; Yang Zhenlin;
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作者单位

Shandong Univ Qilu Hosp Dept Breast Surg Jinan 250012 Shandong Peoples R China;

Binzhou Med Univ Dept Rehabil Med Affiliated Hosp Binzhou 256603 Peoples R China;

Binzhou Med Univ Dept Thyroid &

Breast Surg Affiliated Hosp 661 Huangheer Rd Binzhou 256603;

Binzhou Med Univ Dept Thyroid &

Breast Surg Affiliated Hosp 661 Huangheer Rd Binzhou 256603;

Binzhou Med Univ Dept Thyroid &

Breast Surg Affiliated Hosp 661 Huangheer Rd Binzhou 256603;

Binzhou Med Univ Dept Thyroid &

Breast Surg Affiliated Hosp 661 Huangheer Rd Binzhou 256603;

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原文格式 PDF
正文语种 eng
中图分类妇产科学;
关键词
Breast cancer; MicroRNA-181b; PARP1; Alkylating chemotherapeutic agent; MNNG;

机译：乳腺癌;microRNA-181B;PARP1;烷基化化学治疗剂;MNNG;

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专利

1. Down-regulation of PARP1 by miR-891b sensitizes human breast cancer cells to alkylating chemotherapeutic drugs [J] . Xu Shujian, Zhao Cui, Jia Zhongming, Archives of gynecology and obstetrics. . 2017,第3期

机译：MiR-891B的PARP1的下调使人乳腺癌细胞敏化为烷基化化学治疗药物
2. Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair [J] . Dominika Tempka, Paulina Tokarz, Kinga Chmielewska, Redox Biology . 2018,第1期

机译：CDK4 / 6抑制剂对PARP1转录的下调通过削弱OGG1依赖性碱基切除修复而使人肺癌细胞对抗癌药物诱导的死亡敏感
3. Berberine attenuates XRCC1‐mediated base excision repair and sensitizes breast cancer cells to the chemotherapeutic drugs [J] . Xingjie Gao, Jing Wang, Meiqi Li, Journal of cellular and molecular medicine. . 2019,第10期

机译：小ber碱减弱XRCC1介导的碱基切除修复，并使乳腺癌细胞对化疗药物敏感
4. STUDY THE EFFECT OF ANTICANCER DRUGS ON HUMAN BREAST CANCER CELLS USING THREE DIMENSIONAL SILICON MICROSTRUCTURES [C] . Mehdi Nikkhah, Jeannine S. Strobl, Masoud Agah IMECE2008;ASME international mechanical engineering congress and exposition . 2009

机译：三维硅微结构研究抗癌药物对人乳腺癌细胞的作用
5. Adenoviral overexpression of N-methylpurine DNA glycosylase (MPG) sensitizes breast cancer cells to alkylating agent chemotherapy. [D] . Rinne, Mikael. 2004

机译：N-甲基嘌呤DNA糖基化酶（MPG）的腺病毒过表达使乳腺癌细胞对烷化剂化学疗法敏感。
6. Artichoke Polyphenols Sensitize Human Breast Cancer Cells to Chemotherapeutic Drugs via a ROS-Mediated Downregulation of Flap Endonuclease 1 [O] . Anna Maria Mileo, Donato Di Venere, Stefania Mardente, 2020

机译：朝鲜蓟多酚通过ROS介导的瓣内切核酸酶1下调使人乳腺癌细胞对化疗药物敏感。
7. Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair [O] . Tempka, Dominika, Tokarz, Paulina, Chmielewska, Kinga, 2018

机译：CDK4 / 6抑制剂对paRp1转录的下调通过OGG1依赖性碱基切除修复使人肺癌细胞对抗癌药物诱导的死亡敏感
8. DNA Base Excision Repair (BER) and Cancer Gene Therapy: Use of the Human N-mythlpurien DNA Glycosylase (MPG) to Sensitize Breast Cancer Cells to Low Dose Chemotherapy [R] . Harvey, T. , Kelly, M. R. 2003

机译：DNa碱基切除修复（BER）和癌症基因治疗：使用人类N-mythlpurien DNa糖基化酶（mpG）使乳腺癌细胞对低剂量化疗敏感

Down-regulation of PARP1 by miR-891b sensitizes human breast cancer cells to alkylating chemotherapeutic drugs

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