Synthesis of Pyridothiazepines via a 1,5-Dipolar Cycloaddition Reaction between Pyridinium 1,4-Zwitterionic Thiolates and Activated Allenes

摘要

The synthesis of pyridothiazepines has been achieved via a 1,5-dipolar cycloaddition reaction between pyridinium 1,4-zwitterionic thiolates and activated allenes conducted under thermal conditions. Meanwhile, a ring-contraction reaction of the resulting pyridothiazepine derivatives via the extrusion of 3-thioxoacrylates has also been described.