Primary Mediastinal Yolk Sac Tumors: An Immunohistochemical Analysis of 14 Cases

摘要

Germ cell tumors (GCT) are among the most common tumors in adolescent and young adult males contributing significantly to cancer-related deaths in this age group.1'2 Although the majority of these tumors arise in the gonads, extragonadal GCT can develop from germ cell precursors that become displaced during embryologic migration.3"5 Such "ectopic" GCT have been described in anatomic locations such as the central nervous system, mediastinum, retroperitoneum, and sacrococcygeal region, although their incidence in these sites is very low overall accounting for < 10% of all GCT.