Comparison of accelerated and real-time cyclosporine A release testing from poly(l-lactide-co-trimethylene carbonate) matrices.

摘要

Cyclosporine A (CyA) is a cyclic undecapep-tide, used in prophylaxis and therapy of graft rejection in all types of solid organ and bone narrow transplantations, as well as in treatment of a number of autoimmune diseases. However, prolonged repeated treatment with CyA may cause many side effects like nephrotoxicity, gingival hyperplasia and neurological disorders (1). Several controlled delivery systems of CyA has been studied so far as microspheres and nanospheres based on biodegradable aliphatic polyesters including poly(lactide-co-glycolide), polylactide, and poly(e-caprolactone) (1, 2). Copolymers of TMC with L-lactide may be interesting in developing alternative delivery systems of cyclosporine A. PTMC degrades by surface erosion without acidic products, that could allow to obtain zero order drug release kinetics as well as protection of labile drug molecules (3, 4).