Induction chemotherapy (IC) followed by radiotherapy (RT) versus cetuximab plus IC and RT in advanced laryngeal/hypopharyngeal cancer resectable only by total laryngectomy-final results of the larynx organ preservation trial DeLOS-II

Dietz A.; Wichmann G.; Kuhnt T.; Pfreundner L.; Hagen R.; Scheich M.; Koelbl O.; Hautmann M. G.; Strutz J.; Schreiber F.; Bockmuehl U.; Schilling V.; Feyer P.; de Wit M.; Maschmeyer G.; Jungehuelsing M.; Schroeder U.; Wollenberg B.; Sittel C.; Muenter M.; Lenarz T.; Klussmann J. P.; Guntinas-Lichius O.; Rudack C.; Eich H. T.; Foerg T.; Preyer S.; Westhofen M.; Welkoborsky H. J.; Esser D.; Thurnher D.; Remmert S.; Sudhoff H.; Goerner M.; Buenzel J.; Budach V.; Held S.; Knoedler M.; Lordick F.; Wiegand S.; Vogel K.; Boehm A.; Flentje M.; Keilholz U.

首页> 外文期刊>Annals of oncology: official journal of the European Society for Medical Oncology >Induction chemotherapy (IC) followed by radiotherapy (RT) versus cetuximab plus IC and RT in advanced laryngeal/hypopharyngeal cancer resectable only by total laryngectomy-final results of the larynx organ preservation trial DeLOS-II

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Induction chemotherapy (IC) followed by radiotherapy (RT) versus cetuximab plus IC and RT in advanced laryngeal/hypopharyngeal cancer resectable only by total laryngectomy-final results of the larynx organ preservation trial DeLOS-II

机译：感应化疗（IC）随后是放疗（RT）与甲磺酸/后癌症和室温下的RT可转移只能通过喉喉射精术最终结果进行可转让的喉头植物保存试验DELOS-II

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Background: The German multicenter randomized phase II larynx organ preservation (LOP) trial DeLOS-II was carried out to prove the hypothesis that cetuximab (E) added to induction chemotherapy (IC) and radiotherapy improves laryngectomy-free survival (LFS; survival with preserved larynx) in locally advanced laryngeal/hypopharyngeal cancer (LHSCC).

机译：背景：德国多中心随机阶段II喉风器官保存（LOP）试验DELOS-II进行了证明，以证明加入诱导化疗（IC）和放射治疗的规定，提高了无喉切除存活（LFS;保存的生存喉喉部）在局部晚期喉/下白癌（LHSCC）中。

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来源
《Annals of oncology: official journal of the European Society for Medical Oncology》 |2018年第10期|共10页
作者
Dietz A.; Wichmann G.; Kuhnt T.; Pfreundner L.; Hagen R.; Scheich M.; Koelbl O.; Hautmann M. G.; Strutz J.; Schreiber F.; Bockmuehl U.; Schilling V.; Feyer P.; de Wit M.; Maschmeyer G.; Jungehuelsing M.; Schroeder U.; Wollenberg B.; Sittel C.; Muenter M.; Lenarz T.; Klussmann J. P.; Guntinas-Lichius O.; Rudack C.; Eich H. T.; Foerg T.; Preyer S.; Westhofen M.; Welkoborsky H. J.; Esser D.; Thurnher D.; Remmert S.; Sudhoff H.; Goerner M.; Buenzel J.; Budach V.; Held S.; Knoedler M.; Lordick F.; Wiegand S.; Vogel K.; Boehm A.; Flentje M.; Keilholz U.;
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作者单位

Univ Leipzig Dept Otolaryngol Head &

Neck Surg Liebigstr 10-14 D-04103 Leipzig Germany;

Univ Leipzig Dept Otolaryngol Head &

Neck Surg Liebigstr 10-14 D-04103 Leipzig Germany;

Univ Leipzig Dept Radiat Oncol Leipzig Germany;

Univ Wurzburg Dept Radiat Oncol Wurzburg Germany;

Univ Wurzburg Dept Otolaryngol Head &

Neck Surg Wurzburg Germany;

Univ Wurzburg Dept Otolaryngol Head &

Neck Surg Wurzburg Germany;

Univ Regensburg Dept Radiat Oncol Regensburg Germany;

Univ Regensburg Dept Radiat Oncol Regensburg Germany;

Univ Regensburg Dept Otolaryngol Head &

Neck Surg Regensburg Germany;

Klinikum Kassel Dept Otolaryngol Head &

Neck Surg Kassel Germany;

Klinikum Kassel Dept Otolaryngol Head &

Neck Surg Kassel Germany;

Vivantes Dept Otolaryngol Head &

Neck Surg Berlin Germany;

Vivantes Dept Radiat Oncol Berlin Germany;

Vivantes Dept Hematooncol Berlin Germany;

Klinikum Ernst von Bergmann Dept Hematol Oncol &

Palliat Care Potsdam Germany;

Potsdam Klinikum Dept Otolaryngol Head &

Neck Surg Potsdam Germany;

Univ Lubeck Dept Otolaryngol Head &

Neck Surg Lubeck Germany;

Univ Lubeck Dept Otolaryngol Head &

Neck Surg Lubeck Germany;

Katharinen Hosp Dept Otolaryngol Head &

Neck Surg Stuttgart Germany;

Katharinen Hosp Dept Radiat Oncol Stuttgart Germany;

MHH Hannover Dept Otolaryngol Head &

Neck Surg Hannover Germany;

Univ Giessen Dept Otolaryngol Head &

Neck Surg Giessen Germany;

Jena Univ Hosp Dept Otolaryngol Head &

Neck Surg Jena Germany;

Univ Munster Dept Otolaryngol Head &

Neck Surg Munster Germany;

Univ Munster Dept Radiat Oncol Munster Germany;

ViDia Christliche Kliniken Karlsruhe Dept Radiat Oncol St Vincentius Karlsruhe Germany;

ViDia Christliche Kliniken Karlsruhe St Vincentius Dept Otolaryngol Head &

Neck Surg Karlsruhe;

Univ Aachen Dept Otolaryngol Head &

Neck Surg Aachen Germany;

Klinikum Nordstadt Dept Otolaryngol Head &

Neck Surg Hannover Germany;

HELIOS Klin Dept Otolaryngol Head &

Neck Surg Erfurt Germany;

Graz Univ Dept Otolaryngol Head &

Neck Surg Graz Austria;

Malteser Hosp Duisburg Dept Otolaryngol Head &

Neck Surg Duisburg Germany;

Klinikum Bielefeld Dept Otolaryngol Head &

Neck Surg Bielefeld Germany;

Klinikum Bielefeld Dept Hematooncol Bielefeld Germany;

Klinikum Nordhausen Dept Otolaryngol Head &

Neck Surg Nordhausen Germany;

ClinAssess GmbH Leverkusen Germany;

UCCL Dept Oncol Leipzig Germany;

UCCL Dept Oncol Leipzig Germany;

Univ Leipzig Dept Otolaryngol Head &

Neck Surg Liebigstr 10-14 D-04103 Leipzig Germany;

Univ Leipzig Dept Otolaryngol Head &

Neck Surg Liebigstr 10-14 D-04103 Leipzig Germany;

St Georg Hosp Leipzig Dept Otolaryngol Head &

Neck Surg Leipzig Germany;

Univ Wurzburg Dept Radiat Oncol Wurzburg Germany;

Charite Comprehens Canc Ctr Berlin Germany;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
head and neck cancer; laryngeal cancer; hypopharyngeal cancer; larynx organ preservation; head and neck squamous cell carcinoma (HNSCC); induction chemotherapy;

机译：头部和颈部癌症;喉癌;白阴癌;喉风琴保护;头颈鳞状细胞癌（HNSCC）;诱导化疗;

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专利

1. Induction chemotherapy (IC) followed by radiotherapy (RT) versus cetuximab plus IC and RT in advanced laryngeal/hypopharyngeal cancer resectable only by total laryngectomy-final results of the larynx organ preservation trial DeLOS-II [J] . Dietz A., Wichmann G., Kuhnt T., Annals of oncology: official journal of the European Society for Medical Oncology . 2018,第10期

机译：感应化疗（IC）随后是放疗（RT）与甲磺酸/后癌症和室温下的RT可转移只能通过喉喉射精术最终结果进行可转让的喉头植物保存试验DELOS-II
2. Induction chemotherapy with paclitaxel and cisplatin followed by radiotherapy for larynx organ preservation in advanced laryngeal and hypopharyngeal cancer offers moderate late toxicity outcome (DeLOS-I-trial) [J] . Andreas Dietz, Volker Rudat, Jens Dreyhaupt, European Archives of Oto-Rhino-Laryngology . 2009,第8期

机译：紫杉醇和顺铂诱导化疗后放疗用于晚期喉癌和下咽癌的喉器官保存可提供中度晚期毒性结果（DeLOS-I-trial）
3. Induction chemotherapy followed by radiotherapy for larynx preservation in advanced laryngeal and hypopharyngeal cancer: Outcome prediction after one cycle induction chemotherapy by a score based on clinical evaluation, computed tomography-based volumetry and F-18-FDG-PET/CT [J] . Wichmann Gunnar, Krueger Anne, Boehm Andreas, European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2017,第期

机译：诱导化疗随后是喉部喉癌和白阴性癌症的放射治疗：基于临床评价的分数，基于计算机断层摄影的体积和F-18-FDG-PET / CT进行了一次循环诱导化疗后的结果预测
4. Nuclear Medicine Imaging of Locally Advanced Laryngeal and Hypopharyngeal Cancer [C] . A. Medvedeva, V. Chernov, R. Zeltchan, International Conference on Physics of Cancer : Interdisciplinary Problems and Clinical Applications . 2017

机译：核医学成像对局部晚期喉头和白阴性癌
5. Intensity modulated radiotherapy with concurrent chemotherapy for larynx preservation of advanced resectable hypopharyngeal cancer [O] . Wen-Yen Huang, Yee-Min Jen, Chang-Ming Chen, 2010

机译：调强放疗联合化疗治疗晚期可切除下咽癌的喉部保存
6. A1-04: Sequential radio-chemotherapy (RT-CT) versus radiotherapy alone (RT) and concomitant RT-CT versus RT alone in locally advanced non-small cell lung cancer (NSCLC): Two meta-analyses using individual patient data (IPD) from randomised clinical trials (RCTs) [O] . Rolland Estelle, Le Chevalier Thierry, Auperin Anne, 2007

机译：A1-04：在局部晚期非小细胞肺癌（NSCLC）中，连续放疗（RT-CT）与单独放疗（RT）以及伴随RT-CT与单独RT的比较：使用个体患者数据（IPD）进行的两次荟萃分析）来自随机临床试验（RCT）

Induction chemotherapy (IC) followed by radiotherapy (RT) versus cetuximab plus IC and RT in advanced laryngeal/hypopharyngeal cancer resectable only by total laryngectomy-final results of the larynx organ preservation trial DeLOS-II

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