Impact of age on the efficacy of oxaliplatin in the preoperative chemoradiotherapy and adjuvant chemotherapy of rectal cancer: a post hoc analysis of the CAO/ARO/AIO-04 phase III trial

Hofheinz R. -D.; Arnold D.; Fokas E.; Kaufmann M.; Hothorn T.; Folprecht G.; Fietkau R.; Hohenberger W.; Ghadimi M.; Liersch T.; Grabenbauer G. G.; Sauer R.; Roedel C.; Graeven U.

首页> 外文期刊>Annals of oncology: official journal of the European Society for Medical Oncology >Impact of age on the efficacy of oxaliplatin in the preoperative chemoradiotherapy and adjuvant chemotherapy of rectal cancer: a post hoc analysis of the CAO/ARO/AIO-04 phase III trial

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Impact of age on the efficacy of oxaliplatin in the preoperative chemoradiotherapy and adjuvant chemotherapy of rectal cancer: a post hoc analysis of the CAO/ARO/AIO-04 phase III trial

机译：年龄对奥沙利素在术前化学疗法中的疗效和直肠癌辅助化疗的影响：CaO / Aro / AiO-04期III阶段试验的后HOC分析

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Background: The German rectal cancer trial CAO/ARO/AIO-04 has shown a significant benefit in 3-year disease-free survival (DFS) of adding oxaliplatin to a standard preoperative 5-fluorouracil (5-FU)-based chemoradiotherapy (CRT) and adjuvant chemotherapy in patients with locally advanced rectal cancer. The use of oxaliplatin as adjuvant treatment in elderly patients with colon cancer is controversial. We therefore investigated the impact of age on clinical outcome in the CAO/ARO/AIO-04 phase III trial.

机译：背景：德国直肠癌试验Cao / Aro / AiO-04显示了3年的无病生存（DFS）的显着益处，将oxaliplatin添加到标准的术前5-氟尿嘧啶（5-FU） - 基于化学疗法（CRT））局部晚期癌症患者的辅助化疗。在老年结肠癌患者中使用奥沙利铂作为辅助治疗是有争议的。因此，我们调查了年龄对CAO / ARO / AIO-04阶段试验的临床结果的影响。

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《Annals of oncology: official journal of the European Society for Medical Oncology》 |2018年第8期|共7页
作者
Hofheinz R. -D.; Arnold D.; Fokas E.; Kaufmann M.; Hothorn T.; Folprecht G.; Fietkau R.; Hohenberger W.; Ghadimi M.; Liersch T.; Grabenbauer G. G.; Sauer R.; Roedel C.; Graeven U.;
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作者单位

Heidelberg Univ Univ Hosp Mannheim Interdisciplinary Tumor Ctr Heidelberg Germany;

Asklepios Clin Altona Dept Hematol &

Oncol Hamburg Germany;

Goethe Univ Frankfurt Dept Radiotherapy &

Oncol German Canc Res Ctr DKFZ Heidelberg Germany;

Univ Zurich Epidemiol Biostat &

Prevent Inst Zurich Switzerland;

Univ Zurich Epidemiol Biostat &

Prevent Inst Zurich Switzerland;

Univ Hosp Dresden Dept Oncol Dresden Germany;

Univ Erlangen Nurnberg Dept Radiat Therapy Erlangen Germany;

Univ Erlangen Nurnberg Dept Gen &

Visceral Surg Erlangen Germany;

Univ Med Ctr Gottingen Dept Gen Visceral &

Pediat Surg Gottingen Germany;

Univ Med Ctr Gottingen Dept Gen Visceral &

Pediat Surg Gottingen Germany;

DiaCura &

Klinikum Dept Radiat Oncol &

Radiotherapy Coburg Germany;

Univ Erlangen Nurnberg Dept Radiat Therapy Erlangen Germany;

German Canc Consortium DKTK Frankfurt Germany;

Kliniken Maria Hilf GmbH Dept Hematol Oncol &

Gastroenterol Monchengladbach Germany;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
elderly patients; oxaliplatin; efficacy; chemoradiotherapy; rectal cancer;

机译：老年患者;Oxaliplatin;疗效;化学疗法;直肠癌;

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专利

1. Impact of age on the efficacy of oxaliplatin in the preoperative chemoradiotherapy and adjuvant chemotherapy of rectal cancer: a post hoc analysis of the CAO/ARO/AIO-04 phase III trial [J] . Hofheinz R. -D., Arnold D., Fokas E., Annals of oncology: official journal of the European Society for Medical Oncology . 2018,第8期

机译：年龄对奥沙利素在术前化学疗法中的疗效和直肠癌辅助化疗的影响：CaO / Aro / AiO-04期III阶段试验的后HOC分析
2. Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: Results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years [J] . SauerR., LierschT., MerkelS., Journal of Clinical Oncology . 2012,第16期

机译：局部晚期直肠癌的术前放化疗与术后放化疗：中位随访11年后，德国CAO / ARO / AIO-94随机III期试验的结果
3. Oxaliplatin, fluorouracil, and leucovorin versus fluorouracil and leucovorin as adjuvant chemotherapy for locally advanced rectal cancer after preoperative chemoradiotherapy (ADORE): An open-label, multicentre, phase 2, randomised controlled trial [J] . HongY.S., NamB.-H., KimK.-P., The lancet oncology . 2014,第11期

机译：奥沙利铂，氟尿嘧啶和亚叶酸钙与氟尿嘧啶和亚叶酸在术前放化疗后对局部晚期直肠癌的辅助化疗（ADORE）：一项开放性，多中心，2期，随机对照试验
4. The clinical efficacy of transfusion of cytokine-induced killer cells combined with chemotherapy and XiaoJi decoction in patients with stage IIIB/IV non-small cell lung cancer [C] . Liuning Li, Jiaying Liu, Xiaoshu Chai, IEEE International Conference on Bioinformatics and Biomedicine . 2014

机译：细胞因子诱导的杀伤细胞输注结合化学疗法和消积汤治疗IIIB / IV期非小细胞肺癌的临床疗效
5. Subgroup analysis based on prognostic and predictive gene signatures for adjuvant chemotherapy in early-stage non-small-cell lung cancer patients [D] . Pluta, Dustin. 2015

机译：基于预后和预测基因特征的亚组分析用于早期非小细胞肺癌患者的辅助化疗
6. Interim analysis of postoperative chemoradiotherapy with capecitabine and oxaliplatin versus capecitabine alone for pathological stage II and III rectal cancer: a randomized multicenter phase III trial [O] . Yan-Ru Feng, Yuan Zhu, Lu-Ying Liu, 2016

机译：卡培他滨联合奥沙利铂与单用卡培他滨联合化疗治疗病理性II期和III期直肠癌的中期分析：一项随机的多中心III期临床试验
7. O-0028PREOPERATIVE CHEMORADIOTHERAPY AND POSTOPERATIVE CHEMOTHERAPY WITH 5-FLUOROURACIL AND OXALIPLATIN VERSUS 5-FLUOROURACIL ALONE IN LOCALLY ADVANCED RECTAL CANCER: RESULTS OF THE GERMAN CAO/ARO/AIO-04 RANDOMIZED PHASE III TRIAL [O] . Graeven, U., Liersch, T., Fietkau, R., 2017

机译：局部晚期直肠癌的O-0028术前化疗和5-氟尿嘧啶和草酰戊对5氟尿嘧啶的术后化疗：德国CAO / ARO / AIO-04随机III期临床试验的结果

Impact of age on the efficacy of oxaliplatin in the preoperative chemoradiotherapy and adjuvant chemotherapy of rectal cancer: a post hoc analysis of the CAO/ARO/AIO-04 phase III trial

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