A pulsatile release profile, where the drag is released completely after a defined lag time to protect it from degradation and adapt it as needed to circadian rhythms of body functions or diseases, is advantageous for several drugs or therapies. These could be drags that develop biological tolerance, or have an extensive first-pass metabolism, or are targeted to a specific site in the intestinal tract, for instance, to the colon. Several approaches to pulsatile drag delivery exist. Most drag delivery systems contain a drag reservoir, surrounded by a barrier that either erodes, or dissolves, or ruptures. A potential problem with eroding or dissolving systems is the retarded, and therefore not immediate, drag release after the loss of the barrier function, or a premature release, seen in particular with highly water-soluble drags. This will result in the loss of efficacy of drugs, leading to wastage and increase in patient discomfort. This will also result in the increase in the time of covalence a, thereby, increasing healthcare costs. Conventional coatings that are used to prevent the loss of efficacy has the ability to cause adverse and allergic reactions in the body. Therefore, there is a need to develop protective solutions that will maintain the efficacy of the drag and prevent its untimely release.
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